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Cog4 component of oligomeric golgi complex 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361407, updated on 11-Apr-2024

Summary

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Official Symbol
Cog4provided by RGD
Official Full Name
component of oligomeric golgi complex 4provided by RGD
Primary source
RGD:1310549
See related
Ensembl:ENSRNOG00000017745 AllianceGenome:RGD:1310549
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in Golgi organization; Golgi vesicle prefusion complex stabilization; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in Golgi membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in Saul-Wilson syndrome and congenital disorder of glycosylation type IIj. Orthologous to human COG4 (component of oligomeric golgi complex 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 216.9), Kidney (RPKM 214.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q12
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55729854..55763902)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38820478..38854803)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43358057..43391828, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 3 Neighboring gene small nucleolar RNA, C/D box 111 Neighboring gene small nucleolar RNA, C/D box 111B Neighboring gene fucose kinase Neighboring gene uncharacterized LOC134483368 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Richardson BC, et al. Proc Natl Acad Sci U S A, 2009 Aug 11. PMID 19651599, Free PMC Article
  2. Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. Laufman O, et al. EMBO J, 2009 Jul 22. PMID 19536132, Free PMC Article
  3. The binary interacting network of the conserved oligomeric Golgi tethering complex. Loh E, et al. J Biol Chem, 2004 Jun 4. PMID 15047703
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, vesicle recycling within Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Golgi transport complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Golgi transport complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
conserved oligomeric Golgi complex subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108449.1 → NP_001101919.1  conserved oligomeric Golgi complex subunit 4

    See identical proteins and their annotated locations for NP_001101919.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    A0A8I6A3P8, A6IZ72, D3ZZM3
    Related
    ENSRNOP00000023924.4, ENSRNOT00000023927.6
    Conserved Domains (1) summary
    pfam08318
    Location:188 → 497
    COG4; COG4 transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    55729854..55763902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278138.1 → XP_063134208.1  conserved oligomeric Golgi complex subunit 4 isoform X3

  2. XM_063278137.1 → XP_063134207.1  conserved oligomeric Golgi complex subunit 4 isoform X1

  3. XM_039097859.2 → XP_038953787.1  conserved oligomeric Golgi complex subunit 4 isoform X2

    Conserved Domains (1) summary
    pfam08318
    Location:21 → 330
    COG4; COG4 transport protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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