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Nudt7 nudix hydrolase 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361413, updated on 13-Apr-2024

Summary

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Official Symbol
Nudt7provided by RGD
Official Full Name
nudix hydrolase 7provided by RGD
Primary source
RGD:1306719
See related
Ensembl:ENSRNOG00000011976 AllianceGenome:RGD:1306719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including CoA pyrophosphatase activity; acetyl-CoA hydrolase activity; and magnesium ion binding activity. Predicted to be involved in purine nucleoside bisphosphate catabolic process. Predicted to act upstream of or within acetyl-CoA catabolic process and brown fat cell differentiation. Predicted to be located in peroxisome. Orthologous to human NUDT7 (nudix hydrolase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 62.7), Heart (RPKM 60.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nudt7 in Genome Data Viewer
Location:
19q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (59034808..59049148)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (42125679..42151198)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (46455745..46470070)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA40 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 18 Neighboring gene S-phase kinase-associated protein 1, pseudogene 2 Neighboring gene vesicle amine transport 1-like Neighboring gene C-type lectin domain family 3, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein. Abdelraheim SR, et al. Biochem J, 2003 Sep 1. PMID 12790796, Free PMC Article
  2. The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. Gasmi L, et al. Biochem J, 2001 Jul 1. PMID 11415433, Free PMC Article
  3. Multiple mRNA decapping enzymes in mammalian cells. Song MG, et al. Mol Cell, 2010 Nov 12. PMID 21070968, Free PMC Article
  4. Wdnm1-like, a new adipokine with a role in MMP-2 activation. Wu Y, et al. Am J Physiol Endocrinol Metab, 2008 Jul. PMID 18492766, Free PMC Article
  5. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. Ghosh D, et al. J Am Chem Soc, 2010 Mar 24. PMID 20178365

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables coenzyme A diphosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables snoRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within acetyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in acetyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in butyryl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in coenzyme A catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within coenzyme A catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in coenzyme A catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in malonyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in medium-chain fatty-acyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleoside diphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in propionyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in propionyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in succinyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisomal coenzyme A diphosphatase NUDT7
Names
nudix (nucleoside diphosphate linked moiety X)-type motif 7
nudix motif 7
peroxisomal coenzyme A diphosphatase NUDT7-like
NP_001292355.1
NP_001292356.1
XP_017456810.1
XP_038953791.1
XP_038953792.2
XP_063134209.1
XP_063134210.1
XP_063134211.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305426.1 → NP_001292355.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    FM098914, FM122430, JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A1W2Q6B7
    Related
    ENSRNOP00000032779.6, ENSRNOT00000034012.7
    Conserved Domains (1) summary
    cd03426
    Location:41 → 192
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

  2. NM_001305427.1 → NP_001292356.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 2

    See identical proteins and their annotated locations for NP_001292356.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in its 5' UTR and CDS which results in the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    CB582462, FM122430, FM141049, JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IZE0
    Conserved Domains (1) summary
    cd03426
    Location:13 → 142
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    59034808..59049148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278139.1 → XP_063134209.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X1

  2. XM_063278140.1 → XP_063134210.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X2

    UniProtKB/TrEMBL
    D3ZV74

  3. XM_063278141.1 → XP_063134211.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X4

  4. XM_039097863.1 → XP_038953791.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X3

    UniProtKB/TrEMBL
    A6IZD7
    Related
    ENSRNOP00000076192.2, ENSRNOT00000093238.2
    Conserved Domains (1) summary
    cd03426
    Location:65 → 241
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

  5. XM_017601321.2 → XP_017456810.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform X5

    UniProtKB/TrEMBL
    A6IZD7, A6IZD8
    Conserved Domains (1) summary
    cd03426
    Location:65 → 196
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...

  6. XM_039097864.2 → XP_038953792.2  peroxisomal coenzyme A diphosphatase NUDT7 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108450.1: Suppressed sequence

    Description
    NM_001108450.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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