Dbndd1 dysbindin domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dbndd1provided by RGD
Official Full Name: dysbindin domain containing 1provided by RGD
Primary source: RGD:1310008
See related: AllianceGenome:RGD:1310008
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310008
Summary: Predicted to be involved in negative regulation of protein kinase activity. Predicted to be located in cytoplasm. Orthologous to human DBNDD1 (dysbindin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 71.8), Thymus (RPKM 22.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (68447641..68461272, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (51539154..51548441, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (56302704..56311991, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a novel cardiac role of Dysbindin in the activation of RhoA-SRF and MEK1-ERK1 signaling pathways and in the induction of cardiac hypertrophy, is reported.
Title: Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy.
differentially regulated dysbindin isoforms are expressed in rat retina during postnatal maturation. Interestingly, we found that dysbindin is mainly localized in Muller cells.
Title: Developmental expression of dysbindin in Muller cells of rat retina.
Dysbindin was expressed in the cytoplasm of neurons from epileptic specimens, and levels of dysbindin proteins were significantly increased in patients with temporal lobe epilepsy
Title: Upregulation of dysbindin in temporal lobe epileptic foci of human and experimental animals.
dysbindin and its associated complex sort cargoes from cell bodies to the synapse.
Title: The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.
In primary cultured neurons from rat cortex, knockdown of dysbindin-1 decreased both Coronin 1b & Rab13 mRNA levels. mRNA levels of p53 or necdin were unaltered.
Title: Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53.
results indicate possible functions of dysbindin-1 at the postsynapse in the regulation of dendritic spine morphogenesis through the interaction with WAVE2 and Abi-1
Title: Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation.
In primary cultured hippocampal neurons, Munc-18 is involved with dysbindin in synaptic vesicle exocytosis as a dysbindin-interacting protein.
Title: Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related protein.

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General gene information

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Markers

RH132136 (e-PCR)
- UniSTS:215419

BF399501 (e-PCR)
- UniSTS:247708

RH133199 (e-PCR)
- UniSTS:216482

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in negative regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dysbindin domain-containing protein 1

Names: dysbindin (dystrobrevin binding protein 1) domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014156.1 → NP_001014178.2 dysbindin domain-containing protein 1

Status: VALIDATED

Source sequence(s)

BC088277

UniProtKB/Swiss-Prot

Q5M831

UniProtKB/TrEMBL

A0A0A0MXW5

Conserved Domains (1) summary

pfam04440
Location:79 → 215

Dysbindin; Dysbindin (Dystrobrevin binding protein 1)