U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sipa1l2 signal-induced proliferation-associated 1 like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361442, updated on 2-May-2024

Summary

Go to the top of the page Help
Official Symbol
Sipa1l2provided by RGD
Official Full Name
signal-induced proliferation-associated 1 like 2provided by RGD
Primary source
RGD:1306269
See related
Ensembl:ENSRNOG00000019791 AllianceGenome:RGD:1306269
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Spar2; Sersap2
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity. Predicted to be active in cytoplasm. Orthologous to human SIPA1L2 (signal induced proliferation associated 1 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 139.7), Lung (RPKM 120.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19q12
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (70287134..70437810, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (53389792..53540466, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (58236201..58399842, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102557452 Neighboring gene uncharacterized LOC134483660 Neighboring gene SET like protein Neighboring gene uncharacterized LOC120098601

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Variation in SIPA1L2 is correlated with phenotype modification in Charcot- Marie- Tooth disease type 1A. Tao F, et al. Ann Neurol, 2019 Mar. PMID 30706531, Free PMC Article
  2. SPAR2, a novel SPAR-related protein with GAP activity for Rap1 and Rap2. Spilker C, et al. J Neurochem, 2008 Jan. PMID 17961154
  3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In vitro knockdown of SIPA1L2 in Schwannoma cells led to a significant reduction of PMP22 expression.
    Title: Variation in SIPA1L2 is correlated with phenotype modification in Charcot- Marie- Tooth disease type 1A.
  2. SPAR2 is a new RapGAP with specific functions in cerebellar and hippocampal granule cells.
    Title: SPAR2, a novel SPAR-related protein with GAP activity for Rap1 and Rap2.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in presynaptic signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density, intracellular component IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
signal-induced proliferation-associated 1-like protein 2
Names
SIPA1-like protein 2
serine-rich synapse associated protein 2
serine-rich synapse-associated protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009704.2 → NP_001009704.2  signal-induced proliferation-associated 1-like protein 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    Q5JCS6
    UniProtKB/TrEMBL
    F1M8G8
    Related
    ENSRNOP00000026843.7, ENSRNOT00000026843.8
    Conserved Domains (3) summary
    cd00992
    Location:951 → 1021
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:626 → 806
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:1423 → 1666
    SPAR_C; C-terminal domain of SPAR protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    70287134..70437810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772639.3 → XP_008770861.1  signal-induced proliferation-associated 1-like protein 2 isoform X4

    UniProtKB/Swiss-Prot
    Q5JCS6
    UniProtKB/TrEMBL
    A0A8I5ZPJ4
    Related
    ENSRNOP00000080159.1
    Conserved Domains (3) summary
    cd00992
    Location:951 → 1021
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:626 → 806
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:1423 → 1604
    SPAR_C; C-terminal domain of SPAR protein

  2. XM_039097901.2 → XP_038953829.1  signal-induced proliferation-associated 1-like protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q5JCS6
    Conserved Domains (3) summary
    cd00992
    Location:951 → 1021
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:626 → 806
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:1423 → 1622
    SPAR_C; C-terminal domain of SPAR protein

  3. XM_008772638.3 → XP_008770860.1  signal-induced proliferation-associated 1-like protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q5JCS6
    UniProtKB/TrEMBL
    A0A8I6G2L5
    Related
    ENSRNOP00000078337.1
    Conserved Domains (3) summary
    cd00992
    Location:951 → 1021
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:626 → 806
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:1423 → 1648
    SPAR_C; C-terminal domain of SPAR protein

  4. XM_039097900.2 → XP_038953828.1  signal-induced proliferation-associated 1-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5JCS6
    Conserved Domains (3) summary
    cd00992
    Location:951 → 1021
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:626 → 806
    Rap_GAP; Rap/ran-GAP
    pfam11881
    Location:1423 → 1685
    SPAR_C; C-terminal domain of SPAR protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JCS6.1 GenPept UniProtKB/Swiss-Prot:Q5JCS6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous