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Hnrnpul1 heterogeneous nuclear ribonucleoprotein U-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361522, updated on 11-Apr-2024

Summary

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Official Symbol
Hnrnpul1provided by RGD
Official Full Name
heterogeneous nuclear ribonucleoprotein U-like 1provided by RGD
Primary source
RGD:1307456
See related
Ensembl:ENSRNOG00000020683 AllianceGenome:RGD:1307456
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hnrpul1
Summary
Predicted to enable RNA binding activity and enzyme binding activity. Predicted to be involved in RNA processing and response to virus. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Orthologous to human HNRNPUL1 (heterogeneous nuclear ribonucleoprotein U like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 403.0), Spleen (RPKM 309.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hnrnpul1 in Genome Data Viewer
Location:
1q21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (90356182..90391923, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (81228404..81264121, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (82512745..82548446, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transforming growth factor, beta 1 Neighboring gene coiled-coil domain containing 97 Neighboring gene Axl receptor tyrosine kinase Neighboring gene uncharacterized LOC120096893

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1. Kzhyshkowska J, et al. Biochem J, 2001 Sep 1. PMID 11513728, Free PMC Article
  2. Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. Choe EA, et al. J Neurosci, 2007 Aug 29. PMID 17728463, Free PMC Article
  3. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article
  4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein U-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108477.1 → NP_001101947.1  heterogeneous nuclear ribonucleoprotein U-like protein 1

    See identical proteins and their annotated locations for NP_001101947.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473979
    UniProtKB/TrEMBL
    A6J988
    Conserved Domains (4) summary
    smart00513
    Location:3 → 37
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam13671
    Location:424 → 569
    AAA_33; AAA domain
    cd12884
    Location:212 → 389
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:424 → 562
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    90356182..90391923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081811.2 → XP_038937739.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X3

    Conserved Domains (2) summary
    cd12884
    Location:112 → 289
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    pfam13671
    Location:324 → 469
    AAA_33; AAA domain

  2. XM_008758957.4 → XP_008757179.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X2

    See identical proteins and their annotated locations for XP_008757179.1

    Conserved Domains (3) summary
    pfam13671
    Location:325 → 470
    AAA_33; AAA domain
    cd12884
    Location:113 → 290
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:325 → 463
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  3. XM_008758955.3 → XP_008757177.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1

    UniProtKB/TrEMBL
    D4A962
    Related
    ENSRNOP00000028100.5
    Conserved Domains (4) summary
    smart00513
    Location:3 → 37
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam13671
    Location:425 → 570
    AAA_33; AAA domain
    cd12884
    Location:213 → 390
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:425 → 563
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  4. XM_039081808.2 → XP_038937736.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X3

    Conserved Domains (2) summary
    cd12884
    Location:112 → 289
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    pfam13671
    Location:324 → 469
    AAA_33; AAA domain

  5. XM_008758956.3 → XP_008757178.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X2

    See identical proteins and their annotated locations for XP_008757178.1

    Conserved Domains (3) summary
    pfam13671
    Location:325 → 470
    AAA_33; AAA domain
    cd12884
    Location:113 → 290
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:325 → 463
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
Nucleotide Protein Strain
Heading Accession and Version

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