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Relt RELT, TNF receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 361615, updated on 5-Mar-2024

Summary

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Official Symbol
Reltprovided by RGD
Official Full Name
RELT, TNF receptorprovided by RGD
Primary source
RGD:1305381
See related
Ensembl:ENSRNOG00000025075 AllianceGenome:RGD:1305381
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tnfrsf19l
Summary
Predicted to be involved in amelogenesis and apoptotic process. Predicted to be located in nucleoplasm. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 3C. Orthologous to human RELT (RELT TNF receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 34.4), Muscle (RPKM 27.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Relt in Genome Data Viewer
Location:
1q32
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164619059..164636707, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (155206976..155224609, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165884407..165902022, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RAB6A, member RAS oncogene family Neighboring gene pleckstrin homology domain containing B1 Neighboring gene family with sequence similarity 168, member A Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene microRNA 3102 Neighboring gene pyrimidinergic receptor P2Y6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in RELT cause autosomal recessive amelogenesis imperfecta. Kim JW, et al. Clin Genet, 2019 Mar. PMID 30506946, Free PMC Article
  2. The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation. Polek TC, et al. Biochem Biophys Res Commun, 2006 Apr 28. PMID 16530727
  3. RELT family members activate p38 and induce apoptosis by a mechanism distinct from TNFR1. Moua P, et al. Biochem Biophys Res Commun, 2017 Sep 9. PMID 28688764, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in amelogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amelogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 19L
Names
RELT tumor necrosis factor receptor
tumor necrosis factor receptor superfamily, member 19-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108495.1 → NP_001101965.1  tumor necrosis factor receptor superfamily member 19L precursor

    See identical proteins and their annotated locations for NP_001101965.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473956
    UniProtKB/TrEMBL
    A6I6R8, F1LVW5
    Related
    ENSRNOP00000036110.5, ENSRNOT00000038408.7
    Conserved Domains (2) summary
    cd13419
    Location:26 → 112
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:161 → 196
    RELT; tumor necrosis factor receptor superfamily member 19

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    164619059..164636707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082537.2 → XP_038938465.1  tumor necrosis factor receptor superfamily member 19L isoform X2

    UniProtKB/TrEMBL
    A6I6R8, F1LVW5
    Conserved Domains (2) summary
    cd13419
    Location:26 → 112
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:161 → 196
    RELT; tumor necrosis factor receptor superfamily member 19

  2. XM_006229777.5 → XP_006229839.1  tumor necrosis factor receptor superfamily member 19L isoform X2

    See identical proteins and their annotated locations for XP_006229839.1

    UniProtKB/TrEMBL
    A6I6R8, F1LVW5
    Conserved Domains (2) summary
    cd13419
    Location:26 → 112
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:161 → 196
    RELT; tumor necrosis factor receptor superfamily member 19

  3. XM_006229775.3 → XP_006229837.1  tumor necrosis factor receptor superfamily member 19L isoform X1

    Conserved Domains (2) summary
    cd13419
    Location:73 → 159
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:208 → 243
    RELT; Tumour necrosis factor receptor superfamily member 19

  4. XM_039082543.2 → XP_038938471.1  tumor necrosis factor receptor superfamily member 19L isoform X2

    UniProtKB/TrEMBL
    A6I6R8, F1LVW5
    Conserved Domains (2) summary
    cd13419
    Location:26 → 112
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:161 → 196
    RELT; tumor necrosis factor receptor superfamily member 19

  5. XM_006229780.4 → XP_006229842.1  tumor necrosis factor receptor superfamily member 19L isoform X3

    Conserved Domains (2) summary
    cd13419
    Location:73 → 159
    TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like (TNFRSF19L), also known as receptor expressed in lymphoid tissues (RELT)
    pfam12606
    Location:208 → 243
    RELT; Tumour necrosis factor receptor superfamily member 19
Nucleotide Protein Strain
Heading Accession and Version

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