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Hbb-b1 hemoglobin, beta adult major chain [ Rattus norvegicus (Norway rat) ]

Gene ID: 361619, updated on 2-May-2024

Summary

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Symbol
Hbb-b1provided by RGD
Full Name
hemoglobin, beta adult major chainprovided by RGD
Primary source
RGD:1595848
See related
AllianceGenome:RGD:1595848
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Glna1
Summary
Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to be involved in oxygen transport. Predicted to be part of hemoglobin complex. Orthologous to human HBD (hemoglobin subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 79181.0), Lung (RPKM 19340.1) and 1 other tissue See more
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Genomic context

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Location:
1q32
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (167636064..167643577, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (158224175..158231675, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (168945531..168953023)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily Z member 1 Neighboring gene hemoglobin, beta adult s chain Neighboring gene hemoglobin subunit beta like 1 Neighboring gene hemoglobin, beta adult minor chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. [Isolation and characterization of three rat adult type beta-globin genes]. Inokuchi N. Nihon Ika Daigaku Zasshi, 1994 Nov. PMID 7829656
  2. Genomic organization and characterization of a three-gene rat adult beta-globin haplotype. Au DM, et al. Gene, 1995 Nov 20. PMID 8522187
  3. Characterization of two rat globin cDNA clones. Crkvenjakov R, et al. Hemoglobin, 1984. PMID 6098570
  4. Origin of rat beta-globin haplotypes containing three and five genes. Paunesku T, et al. Mol Biol Evol, 1990 Sep. PMID 2263193
  5. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC72973

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
  
enables oxygen carrier activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in oxygen transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of hemoglobin complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hemoglobin, beta adult major chain
Names
beta-glo
globin a1
hemoglobin beta-chain
hemoglobin subunit beta-2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198776.2 → NP_942071.2  hemoglobin, beta adult major chain

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6AUL4, Q62669
    Conserved Domains (1) summary
    cd08925
    Location:8 → 146
    Hb-beta-like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    167636064..167643577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229913.5 → XP_006229975.3  hemoglobin, beta adult major chain isoform X1

    Conserved Domains (1) summary
    cl21461
    Location:8 → 107
    Globin-like; Globin-like protein superfamily
Nucleotide Protein Strain
Heading Accession and Version

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