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Nsmce1 NSE1 homolog, SMC5-SMC6 complex component [ Rattus norvegicus (Norway rat) ]

Gene ID: 361645, updated on 2-May-2024

Summary

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Official Symbol
Nsmce1provided by RGD
Official Full Name
NSE1 homolog, SMC5-SMC6 complex componentprovided by RGD
Primary source
RGD:1307760
See related
Ensembl:ENSRNOG00000015218 AllianceGenome:RGD:1307760
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307760
Summary
Predicted to enable protein dimerization activity and ubiquitin protein ligase activity. Predicted to be involved in double-strand break repair via homologous recombination; positive regulation of response to DNA damage stimulus; and postreplication repair. Predicted to be located in chromosome, centromeric region; mitotic spindle pole; and nucleoplasm. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Orthologous to human NSMCE1 (NSE1 homolog, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 79.8), Testes (RPKM 67.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nsmce1 in Genome Data Viewer
Location:
1q36
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (189462801..189489188, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (180030355..180058541, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (196857490..196883907, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097358 Neighboring gene lysine demethylase 8 Neighboring gene uncharacterized LOC103691233 Neighboring gene interleukin 4 receptor Neighboring gene uncharacterized LOC120097359

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease. van der Crabben SN, et al. J Clin Invest, 2016 Aug 1. PMID 27427983, Free PMC Article
  2. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. Taylor EM, et al. Mol Cell Biol, 2008 Feb. PMID 18086888, Free PMC Article
  3. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Doyle JM, et al. Mol Cell, 2010 Sep 24. PMID 20864041, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC124662

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein dimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Smc5-Smc6 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Smc5-Smc6 complex IEA
Inferred from Electronic Annotation
more info
  
part_of Smc5-Smc6 complex ISO
Inferred from Sequence Orthology
more info
  
part_of Smc5-Smc6 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle pole IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
non-structural maintenance of chromosomes element 1 homolog
Names
non-SMC element 1 homolog
NP_001034700.1
XP_006230353.1
XP_006230355.1
XP_038938809.1
XP_063123727.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039611.1 → NP_001034700.1  non-structural maintenance of chromosomes element 1 homolog

    See identical proteins and their annotated locations for NP_001034700.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099757
    UniProtKB/TrEMBL
    A0A0G2JSX1, A0A8I6A8T8
    Related
    ENSRNOP00000051912.1, ENSRNOT00000055034.2
    Conserved Domains (2) summary
    pfam07574
    Location:40 → 199
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    pfam08746
    Location:215 → 255
    zf-RING-like; RING-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    189462801..189489188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230291.5 → XP_006230353.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

    See identical proteins and their annotated locations for XP_006230353.1

    UniProtKB/Swiss-Prot
    Q499U6
    UniProtKB/TrEMBL
    A0A8I6A8T8, A6I913
    Related
    ENSRNOP00000089477.1
    Conserved Domains (2) summary
    cd16493
    Location:190 → 234
    RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
    pfam07574
    Location:16 → 175
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

  2. XM_063267657.1 → XP_063123727.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q499U6
    UniProtKB/TrEMBL
    A6I913

  3. XM_006230293.5 → XP_006230355.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

    See identical proteins and their annotated locations for XP_006230355.1

    UniProtKB/Swiss-Prot
    Q499U6
    UniProtKB/TrEMBL
    A0A8I6A8T8, A6I913
    Conserved Domains (2) summary
    cd16493
    Location:190 → 234
    RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
    pfam07574
    Location:16 → 175
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

  4. XM_039082881.2 → XP_038938809.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q499U6
    UniProtKB/TrEMBL
    A0A8I6A8T8, A6I913
    Conserved Domains (2) summary
    cd16493
    Location:190 → 234
    RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
    pfam07574
    Location:16 → 175
    SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q499U6.2 GenPept UniProtKB/Swiss-Prot:Q499U6

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