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Srcap Snf2-related CREBBP activator protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 361652, updated on 2-May-2024

Summary

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Symbol
Srcapprovided by RGD
Full Name
Snf2-related CREBBP activator proteinprovided by RGD
Primary source
RGD:1565642
See related
Ensembl:ENSRNOG00000050282 AllianceGenome:RGD:1565642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565642
Summary
Predicted to enable ATP binding activity; ATP-dependent chromatin remodeler activity; and DNA binding activity. Predicted to be located in Golgi apparatus; nuclear body; and perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in Floating-Harbor syndrome. Orthologous to human SRCAP (Snf2 related CREBBP activator protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 109.7), Spleen (RPKM 102.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Srcap in Genome Data Viewer
Location:
1q37
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191554043..191607096)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182123562..182172643)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198957764..199007576)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene fibrosin Neighboring gene uncharacterized LOC120099937 Neighboring gene small nucleolar RNA, H/ACA box 30 Neighboring gene transmembrane protein 265 Neighboring gene phosphorylase kinase catalytic subunit gamma 2 Neighboring gene cilia and flagella associated protein 119 Neighboring gene ring finger protein 40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
helicase SRCAP
Names
helicase SRCAP-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426934.1 → NP_001413863.1  helicase SRCAP

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZYJ1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    191554043..191607096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101211.2 → XP_038957139.1  helicase SRCAP isoform X3

    UniProtKB/TrEMBL
    A0A8I6AE82, M0R750
    Related
    ENSRNOP00000065268.2
    Conserved Domains (5) summary
    PHA03247
    Location:1259 → 1796
    PHA03247; large tegument protein UL36; Provisional
    PRK04863
    Location:2183 → 2276
    mukB; chromosome partition protein MukB
    cd18793
    Location:1962 → 2097
    SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
    cd18003
    Location:626 → 848
    DEXQc_SRCAP; DEXH/Q-box helicase domain of SRCAP
    pfam07529
    Location:127 → 196
    HSA

  2. XM_039101210.2 → XP_038957138.1  helicase SRCAP isoform X2

    UniProtKB/TrEMBL
    A0A8I6AE82
    Conserved Domains (5) summary
    PHA03247
    Location:1271 → 1856
    PHA03247; large tegument protein UL36; Provisional
    PRK04863
    Location:2243 → 2336
    mukB; chromosome partition protein MukB
    cd18793
    Location:2022 → 2157
    SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
    cd18003
    Location:625 → 847
    DEXQc_SRCAP; DEXH/Q-box helicase domain of SRCAP
    pfam07529
    Location:127 → 196
    HSA

  3. XM_063267796.1 → XP_063123866.1  helicase SRCAP isoform X4

  4. XM_039101209.2 → XP_038957137.1  helicase SRCAP isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYJ1, A0A8I6AE82
    Conserved Domains (5) summary
    PHA03247
    Location:1272 → 1857
    PHA03247; large tegument protein UL36; Provisional
    PRK04863
    Location:2244 → 2337
    mukB; chromosome partition protein MukB
    cd18793
    Location:2023 → 2158
    SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
    cd18003
    Location:626 → 848
    DEXQc_SRCAP; DEXH/Q-box helicase domain of SRCAP
    pfam07529
    Location:127 → 196
    HSA

  5. XM_017590233.3 → XP_017445722.1  helicase SRCAP isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYJ1, A0A8I6AE82
    Conserved Domains (5) summary
    PHA03247
    Location:1272 → 1857
    PHA03247; large tegument protein UL36; Provisional
    PRK04863
    Location:2244 → 2337
    mukB; chromosome partition protein MukB
    cd18793
    Location:2023 → 2158
    SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
    cd18003
    Location:626 → 848
    DEXQc_SRCAP; DEXH/Q-box helicase domain of SRCAP
    pfam07529
    Location:127 → 196
    HSA

  6. XM_063267792.1 → XP_063123862.1  helicase SRCAP isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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