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Plekha1 pleckstrin homology domain containing A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361659, updated on 13-Apr-2024

Summary

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Official Symbol
Plekha1provided by RGD
Official Full Name
pleckstrin homology domain containing A1provided by RGD
Primary source
RGD:1564153
See related
Ensembl:ENSRNOG00000020497 AllianceGenome:RGD:1564153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564153
Summary
Predicted to enable PDZ domain binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in several processes, including B cell receptor signaling pathway; negative regulation of protein kinase B signaling; and phosphatidylinositol 3-kinase signaling. Predicted to act upstream of or within several processes, including cellular hormone metabolic process; face morphogenesis; and gonad development. Predicted to be located in cytosol; nucleoplasm; and ruffle membrane. Predicted to be active in cytoplasm and membrane. Orthologous to human PLEKHA1 (pleckstrin homology domain containing A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 273.5), Brain (RPKM 211.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plekha1 in Genome Data Viewer
Location:
1q41
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (194858239..194909418)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (185427982..185479157)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (201429716..201481411)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transforming, acidic coiled-coil containing protein 2 Neighboring gene uncharacterized LOC134483936 Neighboring gene BTB domain containing 16 Neighboring gene uncharacterized LOC134485181 Neighboring gene HtrA serine peptidase 1 Neighboring gene deleted in malignant brain tumors 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization. Hogan A, et al. J Biol Chem, 2004 Dec 17. PMID 15485858
  2. TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor. Marshall AJ, et al. Mol Cell Biol, 2002 Aug. PMID 12101241, Free PMC Article
  3. Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains. Manna D, et al. J Biol Chem, 2007 Nov 2. PMID 17823121
  4. Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. Kimber WA, et al. Biochem J, 2002 Feb 1. PMID 11802782, Free PMC Article
  5. Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1. Kimber WA, et al. Biochem J, 2003 Dec 1. PMID 14516276, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC156706

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Leydig cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within androgen metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within estrogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within face morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within female gonad development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within luteinization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within roof of mouth development ISO
Inferred from Sequence Orthology
more info
  
involved_in ruffle organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family A member 1
Names
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
pleckstrin homology domain-containing protein family A member 1
tandem PH domain containing protein-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079894.2 → NP_001073363.1  pleckstrin homology domain-containing family A member 1 isoform 2

    See identical proteins and their annotated locations for NP_001073363.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZUX8, A1A5P7
    Related
    ENSRNOP00000027836.3, ENSRNOT00000027836.5
    Conserved Domains (3) summary
    cd13270
    Location:1 → 117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185 → 296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:192 → 288
    PH; PH domain

  2. NM_001415980.1 → NP_001402909.1  pleckstrin homology domain-containing family A member 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    194858239..194909418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267889.1 → XP_063123959.1  pleckstrin homology domain-containing family A member 1 isoform X10

  2. XM_039083107.2 → XP_038939035.1  pleckstrin homology domain-containing family A member 1 isoform X1

    Conserved Domains (2) summary
    cd13270
    Location:1 → 117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:195 → 306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

  3. XM_039083132.2 → XP_038939060.1  pleckstrin homology domain-containing family A member 1 isoform X4

    Conserved Domains (2) summary
    cd13270
    Location:1 → 117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:195 → 306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

  4. XM_006230412.5 → XP_006230474.1  pleckstrin homology domain-containing family A member 1 isoform X6

    Conserved Domains (3) summary
    cd13270
    Location:1 → 117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:195 → 306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:202 → 298
    PH; PH domain

  5. XM_006230413.5 → XP_006230475.1  pleckstrin homology domain-containing family A member 1 isoform X9

    Conserved Domains (3) summary
    cd13271
    Location:195 → 306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:202 → 298
    PH; PH domain
    cl17171
    Location:1 → 117
    PH-like; Pleckstrin homology-like domain

  6. XM_006230409.5 → XP_006230471.1  pleckstrin homology domain-containing family A member 1 isoform X2

    See identical proteins and their annotated locations for XP_006230471.1

    Conserved Domains (3) summary
    cd13270
    Location:1 → 117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:195 → 306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:202 → 298
    PH; PH domain

  7. XM_039083129.2 → XP_038939057.1  pleckstrin homology domain-containing family A member 1 isoform X3

    Conserved Domains (2) summary
    cd13270
    Location:1 → 117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185 → 296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

  8. XM_039083140.2 → XP_038939068.1  pleckstrin homology domain-containing family A member 1 isoform X7

    Conserved Domains (2) summary
    cd13270
    Location:1 → 117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185 → 296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

  9. XM_039083142.2 → XP_038939070.1  pleckstrin homology domain-containing family A member 1 isoform X8

    Conserved Domains (2) summary
    cd13270
    Location:1 → 117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:185 → 296
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

  10. XM_063267882.1 → XP_063123952.1  pleckstrin homology domain-containing family A member 1 isoform X5

    UniProtKB/TrEMBL
    A6IA45

  11. XM_039083154.2 → XP_038939082.1  pleckstrin homology domain-containing family A member 1 isoform X11

    Conserved Domains (2) summary
    cd13271
    Location:147 → 258
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    cl17171
    Location:1 → 75
    PH-like; Pleckstrin homology-like domain

  12. XM_039083170.2 → XP_038939098.1  pleckstrin homology domain-containing family A member 1 isoform X13

    Conserved Domains (2) summary
    cd13271
    Location:137 → 248
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    cl17171
    Location:1 → 75
    PH-like; Pleckstrin homology-like domain

  13. XM_039083173.2 → XP_038939101.1  pleckstrin homology domain-containing family A member 1 isoform X15

    Conserved Domains (2) summary
    cd13271
    Location:137 → 248
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    cl17171
    Location:1 → 75
    PH-like; Pleckstrin homology-like domain

  14. XM_039083180.2 → XP_038939108.1  pleckstrin homology domain-containing family A member 1 isoform X17

    Conserved Domains (2) summary
    cd13271
    Location:137 → 248
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    cl17171
    Location:1 → 75
    PH-like; Pleckstrin homology-like domain

  15. XM_063267892.1 → XP_063123962.1  pleckstrin homology domain-containing family A member 1 isoform X14

    UniProtKB/TrEMBL
    A0A0G2K1A8, A6IA46

  16. XM_039083163.2 → XP_038939091.1  pleckstrin homology domain-containing family A member 1 isoform X12

    UniProtKB/TrEMBL
    A0A8I5ZUX8
    Conserved Domains (2) summary
    cd13270
    Location:1 → 117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:195 → 306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

  17. XM_006230415.5 → XP_006230477.1  pleckstrin homology domain-containing family A member 1 isoform X16

    UniProtKB/TrEMBL
    A0A8I5ZUX8
    Conserved Domains (3) summary
    cd13270
    Location:1 → 117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:195 → 306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    pfam00169
    Location:202 → 298
    PH; PH domain

  18. XM_039083114.2 → XP_038939042.1  pleckstrin homology domain-containing family A member 1 isoform X1

    Conserved Domains (2) summary
    cd13270
    Location:1 → 117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:195 → 306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

  19. XM_063267884.1 → XP_063123954.1  pleckstrin homology domain-containing family A member 1 isoform X5

    UniProtKB/TrEMBL
    A6IA45

  20. XM_063267881.1 → XP_063123951.1  pleckstrin homology domain-containing family A member 1 isoform X3

  21. XM_039083115.2 → XP_038939043.1  pleckstrin homology domain-containing family A member 1 isoform X1

    Conserved Domains (2) summary
    cd13270
    Location:1 → 117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:195 → 306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

  22. XM_039083111.2 → XP_038939039.1  pleckstrin homology domain-containing family A member 1 isoform X1

    Conserved Domains (2) summary
    cd13270
    Location:1 → 117
    PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
    cd13271
    Location:195 → 306
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

  23. XM_063267880.1 → XP_063123950.1  pleckstrin homology domain-containing family A member 1 isoform X3

  24. XM_063267879.1 → XP_063123949.1  pleckstrin homology domain-containing family A member 1 isoform X3

  25. XM_063267887.1 → XP_063123957.1  pleckstrin homology domain-containing family A member 1 isoform X8

  26. XM_063267883.1 → XP_063123953.1  pleckstrin homology domain-containing family A member 1 isoform X5

    UniProtKB/TrEMBL
    A6IA45

  27. XM_063267888.1 → XP_063123958.1  pleckstrin homology domain-containing family A member 1 isoform X10

  28. XM_063267896.1 → XP_063123966.1  pleckstrin homology domain-containing family A member 1 isoform X19

  29. XM_039083187.2 → XP_038939115.1  pleckstrin homology domain-containing family A member 1 isoform X18

    Conserved Domains (2) summary
    cd13271
    Location:113 → 224
    PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    cl17171
    Location:1 → 35
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
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