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Tmem138 transmembrane protein 138 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361728, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem138provided by RGD
Official Full Name
transmembrane protein 138provided by RGD
Primary source
RGD:735168
See related
AllianceGenome:RGD:735168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in cilium assembly. Predicted to be located in vacuolar membrane. Predicted to be integral component of membrane. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in Joubert syndrome 16. Orthologous to human TMEM138 (transmembrane protein 138). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 35.5), Lung (RPKM 23.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem138 in Genome Data Viewer
Location:
1q43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216644047..216651091, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207219113..207226159, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226623861..226630911, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene ribosomal protein L31, pseudogene 6 Neighboring gene cytochrome b561 family, member A3 Neighboring gene triokinase and FMN cyclase Neighboring gene damage-specific DNA binding protein 1 Neighboring gene von Willebrand factor C and EGF domains Neighboring gene pepsinogen A5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Evolutionarily assembled cis-regulatory module at a human ciliopathy locus. Lee JH, et al. Science, 2012 Feb 24. PMID 22282472, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC73003

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 138

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198777.2 → NP_942072.2  transmembrane protein 138

    See identical proteins and their annotated locations for NP_942072.2

    Status: VALIDATED

    Source sequence(s)
    BC061578, BF282432
    UniProtKB/Swiss-Prot
    B1WBM3
    Conserved Domains (1) summary
    pfam14935
    Location:38 → 156
    TMEM138; Transmembrane protein 138

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    216644047..216651091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231047.4 → XP_006231109.1  transmembrane protein 138 isoform X2

    See identical proteins and their annotated locations for XP_006231109.1

    Conserved Domains (1) summary
    pfam14935
    Location:6 → 124
    TMEM138; Transmembrane protein 138

  2. XM_006231046.3 → XP_006231108.1  transmembrane protein 138 isoform X1

    See identical proteins and their annotated locations for XP_006231108.1

    UniProtKB/Swiss-Prot
    B1WBM3
    Conserved Domains (1) summary
    pfam14935
    Location:38 → 156
    TMEM138; Transmembrane protein 138

  3. XM_017589444.3 → XP_017444933.1  transmembrane protein 138 isoform X2

    Conserved Domains (1) summary
    pfam14935
    Location:6 → 124
    TMEM138; Transmembrane protein 138

  4. XM_017589443.3 → XP_017444932.1  transmembrane protein 138 isoform X1

    UniProtKB/Swiss-Prot
    B1WBM3
    Conserved Domains (1) summary
    pfam14935
    Location:38 → 156
    TMEM138; Transmembrane protein 138
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1WBM3.1 GenPept UniProtKB/Swiss-Prot:B1WBM3

Gene LinkOut

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