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Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361745, updated on 27-Apr-2024

Summary

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Official Symbol
Smarca2provided by RGD
Official Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2provided by RGD
Primary source
RGD:1302988
See related
Ensembl:ENSRNOG00000011931 AllianceGenome:RGD:1302988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables chromatin binding activity. Involved in spermatid development. Predicted to be located in chromatin; intermediate filament cytoskeleton; and nucleoplasm. Predicted to be part of SWI/SNF complex; nBAF complex; and npBAF complex. Predicted to be active in nucleus. Orthologous to human SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 144.5), Brain (RPKM 123.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Smarca2 in Genome Data Viewer
Location:
1q52
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (233617277..233784908)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (224191125..224358640)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (244615811..244783736)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483984 Neighboring gene uncharacterized LOC103691317 Neighboring gene uncharacterized LOC134483985 Neighboring gene uncharacterized LOC134485214 Neighboring gene uncharacterized LOC108348917

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SWI/SNF chromatin remodeling ATPase Brm regulates the differentiation of early retinal stem cells/progenitors by influencing Brn3b expression and Notch signaling. Das AV, et al. J Biol Chem, 2007 Nov 30. PMID 17855369
  2. Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein. LeGouy E, et al. Dev Dyn, 1998 May. PMID 9603422
  3. Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor. Chiba H, et al. Nucleic Acids Res, 1994 May 25. PMID 8208605, Free PMC Article
  4. Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells. Kondo T, et al. Genes Dev, 2004 Dec 1. PMID 15574597, Free PMC Article
  5. The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest. Müller C, et al. J Biol Chem, 2004 Feb 20. PMID 14660596

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brm/Smarca2 regulates the differentiation of early retinal stem cells/progenitors by influencing Brn3b expression and Notch signaling
    Title: SWI/SNF chromatin remodeling ATPase Brm regulates the differentiation of early retinal stem cells/progenitors by influencing Brn3b expression and Notch signaling.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aortic smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of RSC-type complex IEA
Inferred from Electronic Annotation
more info
  
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
part_of nBAF complex ISO
Inferred from Sequence Orthology
more info
  
part_of npBAF complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable global transcription activator SNF2L2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004446.2 → NP_001004446.2  probable global transcription activator SNF2L2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Related
    ENSRNOP00000016740.3, ENSRNOT00000016740.6

  2. NM_001429133.1 → NP_001416062.1  probable global transcription activator SNF2L2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  3. NM_001429134.1 → NP_001416063.1  probable global transcription activator SNF2L2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  4. NM_001429135.1 → NP_001416064.1  probable global transcription activator SNF2L2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    233617277..233784908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268536.1 → XP_063124606.1  probable global transcription activator SNF2L2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ARN7

  2. XM_063268547.1 → XP_063124617.1  probable global transcription activator SNF2L2 isoform X4

  3. XM_063268552.1 → XP_063124622.1  probable global transcription activator SNF2L2 isoform X5

  4. XM_063268505.1 → XP_063124575.1  probable global transcription activator SNF2L2 isoform X1

    UniProtKB/TrEMBL
    E9PTG1

  5. XM_063268513.1 → XP_063124583.1  probable global transcription activator SNF2L2 isoform X1

    UniProtKB/TrEMBL
    E9PTG1

  6. XM_063268525.1 → XP_063124595.1  probable global transcription activator SNF2L2 isoform X1

    UniProtKB/TrEMBL
    E9PTG1

  7. XM_063268522.1 → XP_063124592.1  probable global transcription activator SNF2L2 isoform X1

    UniProtKB/TrEMBL
    E9PTG1

  8. XM_063268509.1 → XP_063124579.1  probable global transcription activator SNF2L2 isoform X1

    UniProtKB/TrEMBL
    E9PTG1

  9. XM_063268533.1 → XP_063124603.1  probable global transcription activator SNF2L2 isoform X1

    UniProtKB/TrEMBL
    E9PTG1

  10. XM_063268529.1 → XP_063124599.1  probable global transcription activator SNF2L2 isoform X1

    UniProtKB/TrEMBL
    E9PTG1

  11. XM_063268502.1 → XP_063124572.1  probable global transcription activator SNF2L2 isoform X1

    UniProtKB/TrEMBL
    E9PTG1

  12. XM_063268527.1 → XP_063124597.1  probable global transcription activator SNF2L2 isoform X1

    UniProtKB/TrEMBL
    E9PTG1

  13. XM_063268545.1 → XP_063124615.1  probable global transcription activator SNF2L2 isoform X3

  14. XM_063268564.1 → XP_063124634.1  probable global transcription activator SNF2L2 isoform X6

  15. XM_063268556.1 → XP_063124626.1  probable global transcription activator SNF2L2 isoform X6

  16. XM_063268562.1 → XP_063124632.1  probable global transcription activator SNF2L2 isoform X6

  17. XM_063268559.1 → XP_063124629.1  probable global transcription activator SNF2L2 isoform X6

RNA

  1. XR_010055135.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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