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Bicc1 BicC family RNA binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361832, updated on 6-Jun-2024

Summary

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Official Symbol
Bicc1provided by RGD
Official Full Name
BicC family RNA binding protein 1provided by RGD
Primary source
RGD:1307459
See related
Ensembl:ENSRNOG00000000614 AllianceGenome:RGD:1307459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within determination of left/right symmetry; heart development; and kidney development. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in diffuse cystic renal dysplasia. Orthologous to human BICC1 (BicC family RNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 265.9), Heart (RPKM 108.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bicc1 in Genome Data Viewer
Location:
20p11
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (17448745..17685887)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (17449639..17686775)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (18780605..18940429)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548205 Neighboring gene uncharacterized LOC134483894 Neighboring gene uncharacterized LOC102548329 Neighboring gene uncharacterized LOC134483895

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. BICC1 expression is elevated in depressed subjects and contributes to depressive behavior in rodents. Ota KT, et al. Neuropsychopharmacology, 2015 Feb. PMID 25178406, Free PMC Article
  2. Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia. Kraus MR, et al. Hum Mutat, 2012 Jan. PMID 21922595
  3. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings identify a role for increased levels of BICC1 in the pathophysiology of depressive behavior
    Title: BICC1 expression is elevated in depressed subjects and contributes to depressive behavior in rodents.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein bicaudal C homolog 1
Names
bicaudal C homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415073.1 → NP_001402002.1  protein bicaudal C homolog 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A6JKP7, D3ZDJ9
    Related
    ENSRNOP00000000754.6, ENSRNOT00000000754.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    17448745..17685887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098830.2 → XP_038954758.1  protein bicaudal C homolog 1 isoform X1

    UniProtKB/TrEMBL
    A6JKP7
    Conserved Domains (4) summary
    cd09520
    Location:875 → 938
    SAM_BICC1; SAM domain of BICC1 (bicaudal) subfamily
    cd22420
    Location:48 → 128
    KH-I_BICC1_rpt1; first type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
    cd22421
    Location:133 → 202
    KH-I_BICC1_rpt2; second type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
    cd22422
    Location:286 → 351
    KH-I_BICC1_rpt3; third type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins

  2. XM_039098831.2 → XP_038954759.1  protein bicaudal C homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K0Y0, A6JKP8
    Related
    ENSRNOP00000071622.2
    Conserved Domains (4) summary
    cd09520
    Location:876 → 934
    SAM_BICC1; SAM domain of BICC1 (bicaudal) subfamily
    cd22420
    Location:48 → 128
    KH-I_BICC1_rpt1; first type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
    cd22421
    Location:133 → 202
    KH-I_BICC1_rpt2; second type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
    cd22422
    Location:286 → 351
    KH-I_BICC1_rpt3; third type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins

  3. XM_017601688.3 → XP_017457177.1  protein bicaudal C homolog 1 isoform X3

    UniProtKB/TrEMBL
    A6JKP7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108531.1: Suppressed sequence

    Description
    NM_001108531.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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