Ank3 ankyrin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ank3provided by RGD
Official Full Name: ankyrin 3provided by RGD
Primary source: RGD:620157
See related: Ensembl:ENSRNOG00000053288 AllianceGenome:RGD:620157
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ANK-3
Summary: Enables several functions, including cadherin binding activity; spectrin binding activity; and transmembrane transporter binding activity. Involved in several processes, including clustering of voltage-gated sodium channels; positive regulation of protein targeting to membrane; and regulation of ion transport. Located in several cellular components, including Z disc; main axon; and spectrin-associated cytoskeleton. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ANK3 (ankyrin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 209.2), Brain (RPKM 178.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p11

Exon count:: 57

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (18601307..19224790, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (18602267..19225831, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (19948767..20480628)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ankyrin-G mediates targeting of both Na(+) and KATP channels to the rat cardiac intercalated disc.
Title: Ankyrin-G mediates targeting of both Na(+) and K(ATP) channels to the rat cardiac intercalated disc.
The authors discovered that the entire 24 ankyrin repeats are inhibited by combinatorial and quasi-independent bindings of multiple disordered segments located in the ankyrin-B/G linkers and tails, suggesting a mechanistic basis for differential regulations of membrane target bindings by ankyrins.
Title: Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions.
analysis of structural mechanism by which AnkG anchors to the membrane
Title: Structural basis for the membrane association of ankyrinG via palmitoylation.
The data support a model where ankyrinG-binding is required for preferential Nav1.6 insertion into the axon initial segment plasma membrane during development.
Title: Preferential targeting of Nav1.6 voltage-gated Na+ Channels to the axon initial segment during development.
CK2-regulated IQJC-SCHIP-1 association with AnkG contributes to axon initial segment maintenance.
Title: CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.
the structures of ANK repeats in complex with an inhibitory segment from the C-terminal regulatory domain and with a sodium channel Nav1.2 peptide, are reported.
Title: Structural basis of diverse membrane target recognitions by ankyrins.
The giant exon of AnkG is required for assembly of the AIS and nodes of Ranvier and was a transformative innovation in evolution of the vertebrate nervous system that now is a potential target in neurodevelopmental disorders.
Title: Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling.
ankyrin-G is integral to AMPAR-mediated synaptic transmission and maintenance of spine morphology
Title: Psychiatric risk factor ANK3/ankyrin-G nanodomains regulate the structure and function of glutamatergic synapses.
the ankyrinGbinding motif is both necessary and sufficient for the clustering of sodium channels at nodes of Ranvier and the AIS.
Title: An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier.
The effects of neuroleptic exposure on Ank3 expression in the nodes of Ranvier (NOR) are measured in cerebral cortex of rats receiving long-term haloperidol treatment
Title: Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D20Got27 (e-PCR)
- UniSTS:112402

Ank3 (e-PCR), detects polymorphism
- UniSTS:141079

RH138875 (e-PCR)
- UniSTS:220962

RH138887 (e-PCR)
- UniSTS:220974

BE103415 (e-PCR)
- UniSTS:244811

AA892174 (e-PCR)
- UniSTS:249934

RH131586 (e-PCR)
- UniSTS:214869

RH69744 (e-PCR)
- UniSTS:14961

RH132141 (e-PCR)
- UniSTS:215424

BF405621 (e-PCR)
- UniSTS:247950

BE116351 (e-PCR)
- UniSTS:248472

RH133987 (e-PCR)
- UniSTS:217269

RH118335 (e-PCR)
- UniSTS:160972

AU046827 (e-PCR)
- UniSTS:111098

ANK3 (e-PCR)
- UniSTS:509946

Ank3 (e-PCR), detects polymorphism
- UniSTS:509946

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytoskeletal protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphorylation-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables spectrin binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to magnesium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to magnesium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in clustering of voltage-gated sodium channels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in magnesium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in magnesium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in maintenance of protein location in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protein location in plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in maintenance of protein location in plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in membrane assembly	IEA Inferred from Electronic Annotation more info
involved_in membrane assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular junction development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane organization	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell communication by electrical coupling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of homotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of membrane depolarization during cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sodium ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to axon	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to axon	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of postsynaptic structure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein targeting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
located_in axon initial segment	IEA Inferred from Electronic Annotation more info
located_in axon initial segment	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon initial segment	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in costamere	IDA Inferred from Direct Assay more info	PubMed
located_in costamere	TAS Traceable Author Statement more info	PubMed
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in node of Ranvier	IDA Inferred from Direct Assay more info	PubMed
located_in node of Ranvier	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in paranode region of axon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in spectrin-associated cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ankyrin-3

Names: ankyrin 3 (G); ankyrin 3, epithelial; ankyrin 3, node of Ranvier (ankyrin G); ankyrin-G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033984.1 → NP_001029156.1 ankyrin-3 isoform 2

See identical proteins and their annotated locations for NP_001029156.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longest variant and it encodes the longest protein (isoform 2). Isoform 2 is also known as '270 kDa ankyrin-G'.

Source sequence(s)

AF102552, AJ812023

UniProtKB/Swiss-Prot

O70511, Q574D7, Q574D8, Q574D9, Q574E0, Q574E2, Q8VDA0

UniProtKB/TrEMBL

A6JKS2

Related

ENSRNOP00000088491.1, ENSRNOT00000100191.1

Conserved Domains (7) summary

smart00218
Location:990 → 1094

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:2334 → 2417

Death_ank3; Death domain of Ankyrin-3

cd00204
Location:68 → 193

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:78 → 164

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:639 → 692

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:757 → 811

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:704 → 735

ANK; ANK repeat [structural motif]
NM_031805.2 → NP_113993.1 ankyrin-3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) has a different 5' UTR and multiple differences in the coding region but maintains the reading frame, compared to variant 2. This variant encodes isoform 1 which is shorter than isoform 2. Isoform 1 is also known as AnkG217.

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

O70511

Related

ENSRNOP00000071942.2, ENSRNOT00000090273.2

Conserved Domains (7) summary

smart00218
Location:943 → 1047

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1424 → 1507

Death_ank3; Death domain of Ankyrin-3

cd00204
Location:51 → 176

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:61 → 147

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:614 → 667

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:732 → 786

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:679 → 710

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

18601307..19224790 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279273.1 → XP_063135343.1 ankyrin-3 isoform X32
XM_039098850.2 → XP_038954778.1 ankyrin-3 isoform X37

Conserved Domains (7) summary

smart00218
Location:976 → 1080

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1469 → 1552

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:363 → 651

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:690 → 721

ANK; ANK repeat [structural motif]

pfam13637
Location:757 → 809

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1302 → 1431

UPA_2; UPA domain

cl39094
Location:545 → 782

Ank_2; Ankyrin repeats (3 copies)
XM_063279282.1 → XP_063135352.1 ankyrin-3 isoform X47
XM_063279281.1 → XP_063135351.1 ankyrin-3 isoform X46
XM_063279269.1 → XP_063135339.1 ankyrin-3 isoform X26
XM_063279258.1 → XP_063135328.1 ankyrin-3 isoform X11
XM_063279252.1 → XP_063135322.1 ankyrin-3 isoform X5
XM_063279249.1 → XP_063135319.1 ankyrin-3 isoform X2
XM_063279253.1 → XP_063135323.1 ankyrin-3 isoform X6
XM_063279251.1 → XP_063135321.1 ankyrin-3 isoform X4
XM_063279248.1 → XP_063135318.1 ankyrin-3 isoform X1
XM_063279255.1 → XP_063135325.1 ankyrin-3 isoform X8
XM_063279257.1 → XP_063135327.1 ankyrin-3 isoform X10
XM_063279256.1 → XP_063135326.1 ankyrin-3 isoform X9
XM_063279254.1 → XP_063135324.1 ankyrin-3 isoform X7
XM_063279263.1 → XP_063135333.1 ankyrin-3 isoform X18
XM_063279250.1 → XP_063135320.1 ankyrin-3 isoform X3
XM_063279259.1 → XP_063135329.1 ankyrin-3 isoform X12
XM_063279283.1 → XP_063135353.1 ankyrin-3 isoform X48
XM_063279266.1 → XP_063135336.1 ankyrin-3 isoform X21
XM_063279264.1 → XP_063135334.1 ankyrin-3 isoform X19
XM_063279262.1 → XP_063135332.1 ankyrin-3 isoform X17
XM_063279285.1 → XP_063135355.1 ankyrin-3 isoform X50
XM_039098836.2 → XP_038954764.1 ankyrin-3 isoform X15

UniProtKB/TrEMBL

A0A8I5ZUT6

Conserved Domains (10) summary

smart00218
Location:982 → 1086

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:4041 → 4124

Death_ank3; Death domain of Ankyrin-3

PTZ00449
Location:2044 → 2316

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:369 → 657

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1477 → 1879

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:696 → 727

ANK; ANK repeat [structural motif]

pfam11081
Location:3229 → 3350

DUF2890; Protein of unknown function (DUF2890)

pfam13637
Location:763 → 815

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1308 → 1437

UPA_2; UPA domain

cl39094
Location:551 → 788

Ank_2; Ankyrin repeats (3 copies)
XM_063279261.1 → XP_063135331.1 ankyrin-3 isoform X16
XM_063279284.1 → XP_063135354.1 ankyrin-3 isoform X49
XM_063279260.1 → XP_063135330.1 ankyrin-3 isoform X13
XM_063279265.1 → XP_063135335.1 ankyrin-3 isoform X20
XM_063279267.1 → XP_063135337.1 ankyrin-3 isoform X23
XM_039098838.2 → XP_038954766.1 ankyrin-3 isoform X22

UniProtKB/TrEMBL

A0A8I6A9I9, A6JKS2

Conserved Domains (9) summary

smart00218
Location:990 → 1094

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:2334 → 2417

Death_ank3; Death domain of Ankyrin-3

PTZ00449
Location:2045 → 2317

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1472 → 1880

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:704 → 735

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1316 → 1445

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_039098839.2 → XP_038954767.1 ankyrin-3 isoform X24

Conserved Domains (7) summary

smart00218
Location:982 → 1086

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1475 → 1558

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:369 → 657

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:696 → 727

ANK; ANK repeat [structural motif]

pfam13637
Location:763 → 815

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1308 → 1437

UPA_2; UPA domain

cl39094
Location:551 → 788

Ank_2; Ankyrin repeats (3 copies)
XM_063279268.1 → XP_063135338.1 ankyrin-3 isoform X25
XM_063279271.1 → XP_063135341.1 ankyrin-3 isoform X29
XM_063279270.1 → XP_063135340.1 ankyrin-3 isoform X27
XM_039098842.2 → XP_038954770.1 ankyrin-3 isoform X28

Related

ENSRNOP00000095836.1

Conserved Domains (7) summary

smart00218
Location:982 → 1086

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1475 → 1558

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:369 → 657

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:696 → 727

ANK; ANK repeat [structural motif]

pfam13637
Location:763 → 815

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1308 → 1437

UPA_2; UPA domain

cl39094
Location:551 → 788

Ank_2; Ankyrin repeats (3 copies)
XM_063279272.1 → XP_063135342.1 ankyrin-3 isoform X31
XM_039098844.2 → XP_038954772.1 ankyrin-3 isoform X30

Conserved Domains (7) summary

smart00218
Location:961 → 1065

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1454 → 1537

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:369 → 657

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:696 → 727

ANK; ANK repeat [structural motif]

pfam13637
Location:763 → 815

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1287 → 1416

UPA_2; UPA domain

cl39094
Location:551 → 788

Ank_2; Ankyrin repeats (3 copies)
XM_039098845.2 → XP_038954773.1 ankyrin-3 isoform X33

Conserved Domains (7) summary

smart00218
Location:961 → 1065

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1454 → 1537

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:369 → 657

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:696 → 727

ANK; ANK repeat [structural motif]

pfam13637
Location:763 → 815

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1287 → 1416

UPA_2; UPA domain

cl39094
Location:551 → 788

Ank_2; Ankyrin repeats (3 copies)
XM_063279275.1 → XP_063135345.1 ankyrin-3 isoform X36
XM_063279274.1 → XP_063135344.1 ankyrin-3 isoform X34
XM_063279278.1 → XP_063135348.1 ankyrin-3 isoform X41
XM_039098849.2 → XP_038954777.1 ankyrin-3 isoform X35

Conserved Domains (7) summary

smart00218
Location:982 → 1086

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1475 → 1558

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:369 → 657

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:696 → 727

ANK; ANK repeat [structural motif]

pfam13637
Location:763 → 815

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1308 → 1437

UPA_2; UPA domain

cl39094
Location:551 → 788

Ank_2; Ankyrin repeats (3 copies)
XM_063279277.1 → XP_063135347.1 ankyrin-3 isoform X39
XM_039098851.2 → XP_038954779.1 ankyrin-3 isoform X40

Conserved Domains (7) summary

smart00218
Location:961 → 1065

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1454 → 1537

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:369 → 657

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:696 → 727

ANK; ANK repeat [structural motif]

pfam13637
Location:763 → 815

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1287 → 1416

UPA_2; UPA domain

cl39094
Location:551 → 788

Ank_2; Ankyrin repeats (3 copies)
XM_063279279.1 → XP_063135349.1 ankyrin-3 isoform X42
XM_039098852.2 → XP_038954780.1 ankyrin-3 isoform X43

UniProtKB/TrEMBL

A6JKS7, Q3T1J5

Conserved Domains (3) summary

smart00218
Location:116 → 220

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:609 → 692

Death_ank3; Death domain of Ankyrin-3

pfam17809
Location:442 → 571

UPA_2; UPA domain
XM_063279280.1 → XP_063135350.1 ankyrin-3 isoform X45
XM_039098853.2 → XP_038954781.1 ankyrin-3 isoform X44

UniProtKB/TrEMBL

A6JKS6, Q3T1J5

Conserved Domains (3) summary

smart00218
Location:116 → 220

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:609 → 692

Death_ank3; Death domain of Ankyrin-3

pfam17809
Location:442 → 571

UPA_2; UPA domain
XM_039098834.2 → XP_038954762.1 ankyrin-3 isoform X14

UniProtKB/TrEMBL

A0A8I5ZUT6

Related

ENSRNOP00000082903.1

Conserved Domains (10) summary

smart00218
Location:982 → 1086

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:4041 → 4124

Death_ank3; Death domain of Ankyrin-3

PTZ00449
Location:2044 → 2316

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

PHA03095
Location:369 → 657

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1477 → 1879

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:696 → 727

ANK; ANK repeat [structural motif]

pfam11081
Location:3229 → 3350

DUF2890; Protein of unknown function (DUF2890)

pfam13637
Location:763 → 815

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1308 → 1437

UPA_2; UPA domain

cl39094
Location:551 → 788

Ank_2; Ankyrin repeats (3 copies)
XM_063279276.1 → XP_063135346.1 ankyrin-3 isoform X38