Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ndufaf2provided by RGD
Official Full Name: NADH:ubiquinone oxidoreductase complex assembly factor 2provided by RGD
Primary source: RGD:1560158
See related: Ensembl:ENSRNOG00000055079 AllianceGenome:RGD:1560158
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ndufa12l; RGD1560158
Summary: Predicted to act upstream of or within mitochondrial respiratory chain complex I assembly and negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 10. Orthologous to human NDUFAF2 (NADH:ubiquinone oxidoreductase complex assembly factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 43.0), Muscle (RPKM 37.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (41269141..41380895, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (39535680..39647378, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (39322145..39434535, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mimitin overexpression protected INS1E pancreatic beta cells against cytokine-induced caspase 3 activation, mitochondrial membrane potential reduction and ATP production inhibition.
Title: Effects of the novel mitochondrial protein mimitin in insulin-secreting cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

Names: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2; NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; mimitin, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399052.1 → NP_001385981.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A0G2JZF6, A6I5J8

Related

ENSRNOP00000071027.1, ENSRNOT00000090193.2

Conserved Domains (1) summary

cl01534
Location:23 → 94

NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

41269141..41380895 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103504.2 → XP_038959432.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 isoform X3

Conserved Domains (1) summary

cl01534
Location:23 → 73

NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12
XM_039103501.2 → XP_038959429.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 isoform X1

Conserved Domains (1) summary

cl01534
Location:2 → 49

NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12
XM_039103503.2 → XP_038959431.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 isoform X2

Conserved Domains (1) summary

cl01534
Location:23 → 71

NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12