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Nr6a1 nuclear receptor subfamily 6, group A, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362125, updated on 13-Apr-2024

Summary

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Official Symbol
Nr6a1provided by RGD
Official Full Name
nuclear receptor subfamily 6, group A, member 1provided by RGD
Primary source
RGD:1564740
See related
Ensembl:ENSRNOG00000013232 AllianceGenome:RGD:1564740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gcnf
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within gamete generation and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Orthologous to human NR6A1 (nuclear receptor subfamily 6 group A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 43.3), Kidney (RPKM 29.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nr6a1 in Genome Data Viewer
Location:
3q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (42904832..43094622, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (22495109..22683132, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (23029222..23218050, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 5, group A, member 1 Neighboring gene uncharacterized LOC134486088 Neighboring gene uncharacterized LOC120101539 Neighboring gene microRNA 181a-2 Neighboring gene microRNA 181b-2 Neighboring gene olfactomedin-like 2A Neighboring gene golgin A2 like 2 Neighboring gene small nucleolar RNA SNORA79

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NR6A1 couples with cAMP response element binding protein and regulates vascular smooth muscle cell migration. Wang Y, et al. Int J Biochem Cell Biol, 2015 Dec. PMID 26546462
  2. Spatial and temporal expression of germ cell nuclear factor in murine epididymis. Zhou ZY, et al. Asian J Androl, 2004 Mar. PMID 15064830
  3. Characterization of the response element and DNA binding properties of the nuclear orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor. Yan ZH, et al. J Biol Chem, 1997 Apr 18. PMID 9099702
  4. xGCNF, a nuclear orphan receptor is expressed during neurulation in Xenopus laevis. Joos TO, et al. Mech Dev, 1996 Nov. PMID 9025060
  5. RTR: a new member of the nuclear receptor superfamily that is highly expressed in murine testis. Hirose T, et al. Gene, 1995 Jan 23. PMID 7835709

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NR6A1 regulates SPP1 promoter activity via a putative CRE site.
    Title: NR6A1 couples with cAMP response element binding protein and regulates vascular smooth muscle cell migration.
  2. germ cell nuclear factor (GCNF) may play an important role in epididymal differentiation((Nr6a1).
    Title: Spatial and temporal expression of germ cell nuclear factor in murine epididymis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in gamete generation ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear receptor subfamily 6 group A member 1
Names
germ cell nuclear factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100861.1 → NP_001094331.1  nuclear receptor subfamily 6 group A member 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5Y5U9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    42904832..43094622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106243.2 → XP_038962171.2  nuclear receptor subfamily 6 group A member 1 isoform X3

  2. XM_039106245.2 → XP_038962173.2  nuclear receptor subfamily 6 group A member 1 isoform X5

  3. XM_039106244.2 → XP_038962172.2  nuclear receptor subfamily 6 group A member 1 isoform X4

  4. XM_039106242.2 → XP_038962170.2  nuclear receptor subfamily 6 group A member 1 isoform X2

  5. XM_039106241.2 → XP_038962169.2  nuclear receptor subfamily 6 group A member 1 isoform X1

  6. XM_063284079.1 → XP_063140149.1  nuclear receptor subfamily 6 group A member 1 isoform X8

  7. XM_039106246.2 → XP_038962174.1  nuclear receptor subfamily 6 group A member 1 isoform X7

    UniProtKB/TrEMBL
    A6JEV2, A6JEV3, E9PSV7
    Related
    ENSRNOP00000018751.7
    Conserved Domains (2) summary
    cd06953
    Location:214 → 425
    NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
    cd07169
    Location:10 → 99
    NR_DBD_GCNF_like; DNA-binding domain of Germ cell nuclear factor (GCNF) F1 is composed of two C4-type zinc fingers

  8. XM_063284078.1 → XP_063140148.1  nuclear receptor subfamily 6 group A member 1 isoform X6

Nucleotide Protein Strain
Heading Accession and Version

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