Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chac1provided by RGD
Official Full Name: ChaC glutathione-specific gamma-glutamylcyclotransferase 1provided by RGD
Primary source: RGD:1307153
See related: Ensembl:ENSRNOG00000014387 AllianceGenome:RGD:1307153
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307153
Summary: Predicted to enable Notch binding activity and gamma-glutamylcyclotransferase activity. Predicted to be involved in several processes, including glutathione catabolic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and negative regulation of Notch signaling pathway. Predicted to be located in cytosol and trans-Golgi network. Predicted to be active in cytoplasm. Orthologous to human CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 73.2), Brain (RPKM 23.8) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (126796131..126799352)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (106342302..106345526)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (111160205..111163425)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we found that Botch exerts neuroprotective effects via antagonizing the maturation of Notch1-induced neuronal injury and neuroinflammation after cerebral ischemia-reperfusion (I/R) injury
Title: Botch protects neurons from ischemic insult by antagonizing Notch-mediated neuroinflammation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables Notch binding	ISS Inferred from Sequence or Structural Similarity more info
enables glutathione specific gamma-glutamylcyclotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione specific gamma-glutamylcyclotransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glutathione catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glutathione-specific gamma-glutamylcyclotransferase 1

Names: ChaC, cation transport regulator homolog 1; ChaC, cation transport regulator-like 1; blocks Notch protein; botch; cation transport regulator homolog 1; cation transport regulator-like protein 1; gamma-GCG 1; neuroprotective protein 7

NP_001166908.1

EC 4.3.2.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.