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Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362293, updated on 11-Apr-2024

Summary

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Symbol
Dnajb6provided by RGD
Full Name
DnaJ heat shock protein family (Hsp40) member B6provided by RGD
Primary source
RGD:1308207
See related
Ensembl:ENSRNOG00000010353 AllianceGenome:RGD:1308207
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including ATPase activator activity; chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including intermediate filament organization; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; and negative regulation of inclusion body assembly. Predicted to act upstream of or within several processes, including chorion development; labyrinthine layer development; and protein localization to nucleus. Predicted to be located in several cellular components, including Z disc; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 1. Orthologous to human DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 347.8), Testes (RPKM 286.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnajb6 in Genome Data Viewer
Location:
4q11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (6010081..6232052, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (5452683..5556679, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (2711329..2774969)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene dihydrofolate reductase, pseudogene 1 Neighboring gene interleukin 6 Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene uncharacterized LOC120102202 Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene developmental pluripotency-associated protein 3-like Neighboring gene small ribosomal subunit protein uS19-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6 on Neuronal Survival. Smith C, et al. Mol Neurobiol, 2016 Oct. PMID 26476842, Free PMC Article
  2. Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently. Chuang JZ, et al. J Biol Chem, 2002 May 31. PMID 11896048
  3. Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. Rose JM, et al. Hum Mol Genet, 2011 Jan 1. PMID 20889486, Free PMC Article
  4. The Hsp40 family chaperone protein DnaJB6 enhances Schlafen1 nuclear localization which is critical for promotion of cell-cycle arrest in T-cells. Zhang Y, et al. Biochem J, 2008 Jul 15. PMID 18373498
  5. Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein. Izawa I, et al. J Biol Chem, 2000 Nov 3. PMID 10954706

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results conclude that neurotoxicity resulting from elevated DNAJB6 is cell cycle dependent.
    Title: Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6 on Neuronal Survival.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone-mediated protein folding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chorio-allantoic fusion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chorion development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intermediate filament organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inclusion body assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within syncytiotrophoblast cell differentiation involved in labyrinthine layer development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily B member 6
Names
DnaJ (Hsp40) homolog, subfamily B, member 6
HSJ-2
MRJ
MSJ-1
heat shock protein J2
hsp40 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013209.1 → NP_001013227.1  dnaJ homolog subfamily B member 6

    See identical proteins and their annotated locations for NP_001013227.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078908
    UniProtKB/Swiss-Prot
    Q6AYU3
    UniProtKB/TrEMBL
    A0A8I5ZT18
    Related
    ENSRNOP00000041883.2, ENSRNOT00000035996.4
    Conserved Domains (1) summary
    COG0484
    Location:2 → 107
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    6010081..6232052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286219.1 → XP_063142289.1  dnaJ homolog subfamily B member 6 isoform X6

  2. XM_063286218.1 → XP_063142288.1  dnaJ homolog subfamily B member 6 isoform X5

  3. XM_063286214.1 → XP_063142284.1  dnaJ homolog subfamily B member 6 isoform X1

  4. XM_063286217.1 → XP_063142287.1  dnaJ homolog subfamily B member 6 isoform X4

  5. XM_063286216.1 → XP_063142286.1  dnaJ homolog subfamily B member 6 isoform X2

    UniProtKB/Swiss-Prot
    Q6AYU3

  6. XM_006235864.5 → XP_006235926.2  dnaJ homolog subfamily B member 6 isoform X1

  7. XM_063286220.1 → XP_063142290.1  dnaJ homolog subfamily B member 6 isoform X7

  8. XM_039107734.2 → XP_038963662.1  dnaJ homolog subfamily B member 6 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AML5, A6KJM9
    Related
    ENSRNOP00000093872.1
    Conserved Domains (1) summary
    COG0484
    Location:2 → 107
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RNA

  1. XR_010065653.1 RNA Sequence

  2. XR_010065652.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYU3.1 GenPept UniProtKB/Swiss-Prot:Q6AYU3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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