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Nup205 nucleoporin 205 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362335, updated on 5-Mar-2024

Summary

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Official Symbol
Nup205provided by RGD
Official Full Name
nucleoporin 205provided by RGD
Primary source
RGD:1309413
See related
Ensembl:ENSRNOG00000010852 AllianceGenome:RGD:1309413
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nuclear pore complex assembly. Predicted to be located in nuclear membrane and nuclear periphery. Predicted to be part of nuclear pore inner ring. Human ortholog(s) of this gene implicated in nephrotic syndrome type 13. Orthologous to human NUP205 (nucleoporin 205). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 179.5), Spleen (RPKM 124.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nup205 in Genome Data Viewer
Location:
4q22
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (64822051..64887996)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (63854934..63920852)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (62703779..62773931)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692099 Neighboring gene solute carrier family 23 member 4 Neighboring gene CCR4-NOT transcription complex, subunit 4 Neighboring gene uncharacterized LOC102553126 Neighboring gene large ribosomal subunit protein eL38-like Neighboring gene short transmembrane mitochondrial protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. Krull S, et al. Mol Biol Cell, 2004 Sep. PMID 15229283, Free PMC Article
  2. Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex. Hase ME, et al. Mol Biol Cell, 2003 May. PMID 12802065, Free PMC Article
  3. JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. Lin Z, et al. Aging Cell, 2021 Feb. PMID 33450132, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in nuclear pore complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear pore organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear periphery ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore inner ring IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nuclear pore complex protein Nup205
Names
nucleoporin 205kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108620.1 → NP_001102090.1  nuclear pore complex protein Nup205

    See identical proteins and their annotated locations for NP_001102090.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473959
    UniProtKB/TrEMBL
    A6IEN8, D4A7R3
    Related
    ENSRNOP00000076488.1, ENSRNOT00000098985.1
    Conserved Domains (1) summary
    pfam11894
    Location:14 → 1684
    Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    64822051..64887996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107776.2 → XP_038963704.1  nuclear pore complex protein Nup205 isoform X1

    UniProtKB/TrEMBL
    D4A7R3
    Conserved Domains (1) summary
    pfam11894
    Location:206 → 1725
    Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205

  2. XM_008762797.3 → XP_008761019.1  nuclear pore complex protein Nup205 isoform X2

    See identical proteins and their annotated locations for XP_008761019.1

    UniProtKB/TrEMBL
    A0A8I6GHV1, D4A7R3
    Related
    ENSRNOP00000090010.1
    Conserved Domains (1) summary
    pfam11894
    Location:3 → 1573
    Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205

  3. XM_039107777.1 → XP_038963705.1  nuclear pore complex protein Nup205 isoform X3

    Conserved Domains (1) summary
    cl29134
    Location:1 → 879
    Nup188; Nucleoporin subcomplex protein binding to Pom34
Nucleotide Protein Strain
Heading Accession and Version

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