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INHBA inhibin subunit beta A [ Homo sapiens (human) ]

Gene ID: 3624, updated on 4-Jan-2025

Summary

Official Symbol
INHBAprovided by HGNC
Official Full Name
inhibin subunit beta Aprovided by HGNC
Primary source
HGNC:HGNC:6066
See related
Ensembl:ENSG00000122641 MIM:147290; AllianceGenome:HGNC:6066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDF; FRP
Summary
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]
Expression
Broad expression in endometrium (RPKM 12.3), gall bladder (RPKM 11.3) and 15 other tissues See more
Orthologs
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Genomic context

See INHBA in Genome Data Viewer
Location:
7p14.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (41685114..41705406, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (41843512..41867440, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (41724712..41742688, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375247 Neighboring gene uncharacterized LOC107986789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25899 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:41748736-41749935 Neighboring gene INHBA antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25901 Neighboring gene uncharacterized LOC124901618 Neighboring gene GLI family zinc finger 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:42068797-42069297 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:42105443-42106096 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:42131129-42131824 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 30

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
EBI GWAS Catalog
Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.
EBI GWAS Catalog
Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of inhibin, beta A (INHBA) in human B cells PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of inhibin, beta A (INHBA) in peptide-treated PBMCs PubMed
Tat tat HIV-1 Tat upregulates the expression of inhibin, beta A (INHBA) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • AC005027.3

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity  
enables cytokine activity PubMed 
enables growth factor activity PubMed 
enables hormone activity PubMed 
enables identical protein binding PubMed 
enables peptide hormone binding PubMed 
enables protein binding PubMed 
enables protein-containing complex binding  
enables type II activin receptor binding PubMed 
Items 1 - 25 of 60
Process Evidence Code Pubs
involved_in GABAergic neuron differentiation PubMed 
involved_in SMAD protein signal transduction  
involved_in Sertoli cell differentiation  
involved_in activin receptor signaling pathway PubMed 
involved_in androgen metabolic process  
involved_in androst-4-ene-3,17-dione biosynthetic process  
involved_in autophagy  
involved_in cardiac fibroblast cell development  
involved_in cell differentiation PubMed 
involved_in cell surface receptor signaling pathway PubMed 
involved_in cell-cell signaling PubMed 
involved_in cellular response to angiotensin  
involved_in cellular response to cholesterol  
involved_in cellular response to follicle-stimulating hormone stimulus  
involved_in cellular response to hypoxia  
involved_in cellular response to oxygen-glucose deprivation  
involved_in cytokine-mediated signaling pathway  
involved_in defense response PubMed 
involved_in endodermal cell differentiation PubMed 
involved_in erythrocyte differentiation PubMed 
involved_in extrinsic apoptotic signaling pathway PubMed 
involved_in eyelid development in camera-type eye  
involved_in hair follicle development PubMed 
involved_in hematopoietic progenitor cell differentiation PubMed 
involved_in hemoglobin biosynthetic process PubMed 
involved_in male gonad development PubMed 
involved_in mesodermal cell differentiation  
involved_in negative regulation of B cell differentiation PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle PubMed 
involved_in negative regulation of cell growth PubMed 
involved_in negative regulation of cell population proliferation PubMed 
involved_in negative regulation of follicle-stimulating hormone secretion PubMed 
involved_in negative regulation of macrophage differentiation PubMed 
involved_in negative regulation of phosphorylation PubMed 
involved_in negative regulation of type II interferon production PubMed 
involved_in nervous system development PubMed 
involved_in odontogenesis PubMed 
involved_in ovarian follicle development PubMed 
involved_in ovarian follicle development PubMed 
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of SMAD protein signal transduction PubMed 
involved_in positive regulation of collagen biosynthetic process  
involved_in positive regulation of erythrocyte differentiation PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand PubMed 
involved_in positive regulation of follicle-stimulating hormone secretion PubMed 
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of ovulation  
involved_in positive regulation of protein metabolic process PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase III  
involved_in progesterone secretion PubMed 
involved_in regulation of follicle-stimulating hormone secretion PubMed 
involved_in regulation of transcription by RNA polymerase II PubMed 
involved_in response to aldosterone  
NOT involved_in response to wounding PubMed 
involved_in roof of mouth development PubMed 
involved_in striatal medium spiny neuron differentiation PubMed 
involved_in testosterone biosynthetic process  
involved_in transcription by RNA polymerase II  
Items 1 - 25 of 60
Component Evidence Code Pubs
part_of activin A complex PubMed 
part_of enzyme activator complex PubMed 
located_in extracellular region PubMed 
located_in extracellular region  
is_active_in extracellular space  
part_of inhibin A complex PubMed 
located_in perinuclear region of cytoplasm  

General protein information

Preferred Names
inhibin beta A chain
Names
FSH-releasing protein
Inhibin, beta-1
activin beta-A chain
erythroid differentiation factor
erythroid differentiation protein
follicle-stimulating hormone-releasing protein
inhibin beta A subunit
inhibin, beta A (activin A, activin AB alpha polypeptide)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002192.4NP_002183.1  inhibin beta A chain preproprotein

    See identical proteins and their annotated locations for NP_002183.1

    Status: REVIEWED

    Source sequence(s)
    AA491465, AC005027, AK001903, AU137531, BC007858
    Consensus CDS
    CCDS5464.1
    UniProtKB/Swiss-Prot
    P08476, Q14599
    UniProtKB/TrEMBL
    A4D1W7, Q53H39, Q9HBP0
    Related
    ENSP00000242208.4, ENST00000242208.5
    Conserved Domains (2) summary
    cd19404
    Location:319426
    TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins
    cl02928
    Location:56236
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    41685114..41705406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012174.2XP_016867663.2  inhibin beta A chain isoform X1

    UniProtKB/Swiss-Prot
    P08476, Q14599
    UniProtKB/TrEMBL
    A4D1W7, Q53H39, Q9HBP0
    Related
    ENSP00000490646.1, ENST00000638023.1
  2. XM_047420335.1XP_047276291.1  inhibin beta A chain isoform X1

    UniProtKB/Swiss-Prot
    P08476, Q14599
    UniProtKB/TrEMBL
    A4D1W7, Q53H39, Q9HBP0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    41843512..41867440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358159.1XP_054214134.1  inhibin beta A chain isoform X3

    UniProtKB/TrEMBL
    Q53H39, Q9HBP0
  2. XM_054358157.1XP_054214132.1  inhibin beta A chain isoform X2

  3. XM_054358158.1XP_054214133.1  inhibin beta A chain isoform X2

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