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Slc25a26 solute carrier family 25 member 26 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362403, updated on 25-Apr-2024

Summary

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Official Symbol
Slc25a26provided by RGD
Official Full Name
solute carrier family 25 member 26provided by RGD
Primary source
RGD:1308811
See related
Ensembl:ENSRNOG00000012831 AllianceGenome:RGD:1308811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable S-adenosyl-L-methionine transmembrane transporter activity. Predicted to be involved in S-adenosyl-L-methionine transport. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 28. Orthologous to human SLC25A26 (solute carrier family 25 member 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 110.6), Kidney (RPKM 43.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc25a26 in Genome Data Viewer
Location:
4q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (128591223..128687854)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (127036704..127131026)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (126522335..126615402)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102171 Neighboring gene proteasome 20S subunit alpha 3, pseudogene 3 Neighboring gene leucine-rich repeats and immunoglobulin-like domains 1 Neighboring gene uncharacterized LOC134486819 Neighboring gene apolipoprotein O-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26. Kishita Y, et al. Am J Hum Genet, 2015 Nov 5. PMID 26522469, Free PMC Article
  2. Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution. Agrimi G, et al. Biochem J, 2004 Apr 1. PMID 14674884, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables S-adenosyl-L-methionine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables S-adenosyl-L-methionine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in S-adenosyl-L-methionine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial S-adenosyl-L-methionine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleoside transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial S-adenosylmethionine carrier protein
Names
S-adenosylmethionine mitochondrial carrier protein
solute carrier family 25 (S-adenosylmethionine carrier), member 26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395605.1 → NP_001382534.1  mitochondrial S-adenosylmethionine carrier protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AAR8, A6IBD8
    Related
    ENSRNOP00000089898.1, ENSRNOT00000111792.1
    Conserved Domains (1) summary
    PTZ00168
    Location:21 → 258
    PTZ00168; mitochondrial carrier protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    128591223..128687854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107818.2 → XP_038963746.1  mitochondrial S-adenosylmethionine carrier protein isoform X2

    UniProtKB/TrEMBL
    A6IBD8
    Conserved Domains (1) summary
    PTZ00168
    Location:21 → 206
    PTZ00168; mitochondrial carrier protein; Provisional

  2. XM_063286288.1 → XP_063142358.1  mitochondrial S-adenosylmethionine carrier protein isoform X6

  3. XM_039107819.2 → XP_038963747.1  mitochondrial S-adenosylmethionine carrier protein isoform X3

    Conserved Domains (1) summary
    PTZ00168
    Location:21 → 166
    PTZ00168; mitochondrial carrier protein; Provisional

  4. XM_039107817.2 → XP_038963745.1  mitochondrial S-adenosylmethionine carrier protein isoform X1

    UniProtKB/TrEMBL
    A6IBD8
    Conserved Domains (1) summary
    PTZ00168
    Location:21 → 243
    PTZ00168; mitochondrial carrier protein; Provisional

  5. XM_039107820.2 → XP_038963748.1  mitochondrial S-adenosylmethionine carrier protein isoform X4

    Conserved Domains (2) summary
    PTZ00168
    Location:21 → 207
    PTZ00168; mitochondrial carrier protein; Provisional
    pfam00153
    Location:145 → 217
    Mito_carr; Mitochondrial carrier protein

  6. XM_039107823.2 → XP_038963751.1  mitochondrial S-adenosylmethionine carrier protein isoform X9

    Conserved Domains (1) summary
    pfam00153
    Location:22 → 82
    Mito_carr; Mitochondrial carrier protein

  7. XM_039107822.2 → XP_038963750.1  mitochondrial S-adenosylmethionine carrier protein isoform X8

    Conserved Domains (1) summary
    PTZ00168
    Location:3 → 170
    PTZ00168; mitochondrial carrier protein; Provisional

  8. XM_039107821.2 → XP_038963749.1  mitochondrial S-adenosylmethionine carrier protein isoform X6

    Conserved Domains (1) summary
    PTZ00168
    Location:21 → 166
    PTZ00168; mitochondrial carrier protein; Provisional

  9. XM_063286289.1 → XP_063142359.1  mitochondrial S-adenosylmethionine carrier protein isoform X7

  10. XM_063286287.1 → XP_063142357.1  mitochondrial S-adenosylmethionine carrier protein isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108638.1: Suppressed sequence

    Description
    NM_001108638.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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