U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Runx1t1 RUNX1 partner transcriptional co-repressor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362489, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Runx1t1provided by RGD
Official Full Name
RUNX1 partner transcriptional co-repressor 1provided by RGD
Primary source
RGD:1305490
See related
Ensembl:ENSRNOG00000005673 AllianceGenome:RGD:1305490
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cbfa2t1
Summary
Predicted to enable DNA-binding transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of fat cell differentiation and negative regulation of transcription, DNA-templated. Predicted to act upstream of or within fat cell differentiation; regulation of DNA binding activity; and regulation of transcription, DNA-templated. Predicted to be located in nuclear matrix and nucleoplasm. Predicted to be active in nucleus. Orthologous to human RUNX1T1 (RUNX1 partner transcriptional co-repressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 31.0), Brain (RPKM 29.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Runx1t1 in Genome Data Viewer
Location:
5q13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (31984946..32136878)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (27187674..27338070)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (27284921..27440802)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transfer RNA threonine (anticodon AGU) 10 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene RUNX1 partner transcriptional co-repressor 1 like Neighboring gene uncharacterized LOC134478936 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Runx1t1 regulates the neuronal differentiation of radial glial cells from the rat hippocampus. Linqing Z, et al. Stem Cells Transl Med, 2015 Jan. PMID 25473084, Free PMC Article
  2. Mutational analysis of RUNX1T1 gene in acute leukemias, breast and lung carcinomas. Kim YR, et al. Leuk Res, 2011 Sep. PMID 21571369
  3. ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis. Rochford JJ, et al. Mol Cell Biol, 2004 Nov. PMID 15509789, Free PMC Article
  4. Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription. Wood JD, et al. J Cell Biol, 2000 Sep 4. PMID 10973986, Free PMC Article
  5. Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins. Indjeian VB, et al. Cell, 2016 Jan 14. PMID 26774823, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We have concluded that Runx1t1 could be involved in the process through which radial glial cells differentiate into neurons
    Title: Runx1t1 regulates the neuronal differentiation of radial glial cells from the rat hippocampus.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein CBFA2T1
Names
CBFA2T1 identified gene homolog
RUNX1 translocation partner 1
acute myelogenous leukemia 1 translocation 1 protein
core-binding factor, runt domain, alpha subunit 2, translocated to, 1
core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related
cyclin D-related
runt-related transcription factor 1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
translocated to, 1 (cyclin D-related)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108657.1 → NP_001102127.1  protein CBFA2T1

    See identical proteins and their annotated locations for NP_001102127.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473962
    UniProtKB/TrEMBL
    A6II90, D3ZWZ8
    Related
    ENSRNOP00000063830.1, ENSRNOT00000066191.2
    Conserved Domains (4) summary
    COG1390
    Location:416 → 487
    NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
    pfam08788
    Location:310 → 376
    NHR2; NHR2 domain like
    pfam01753
    Location:488 → 524
    zf-MYND; MYND finger
    pfam07531
    Location:95 → 183
    TAFH; NHR1 homology to TAF

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    31984946..32136878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237901.5 → XP_006237963.1  protein CBFA2T1 isoform X1

    See identical proteins and their annotated locations for XP_006237963.1

    UniProtKB/TrEMBL
    A0A0G2K0G0
    Conserved Domains (4) summary
    COG1390
    Location:443 → 514
    NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
    pfam08788
    Location:337 → 403
    NHR2; NHR2 domain like
    pfam01753
    Location:515 → 551
    zf-MYND; MYND finger
    pfam07531
    Location:122 → 210
    TAFH; NHR1 homology to TAF

  2. XM_006237904.5 → XP_006237966.1  protein CBFA2T1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6G5L4
    Related
    ENSRNOP00000081192.1
    Conserved Domains (5) summary
    TIGR02794
    Location:372 → 483
    tolA_full; TolA protein
    pfam01753
    Location:495 → 531
    zf-MYND; MYND finger
    pfam07531
    Location:102 → 188
    TAFH; NHR1 homology to TAF
    pfam08788
    Location:317 → 383
    NHR2; NHR2 domain like
    cl23750
    Location:421 → 477
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

  3. XM_008763550.4 → XP_008761772.1  protein CBFA2T1 isoform X1

    See identical proteins and their annotated locations for XP_008761772.1

    UniProtKB/TrEMBL
    A0A0G2K0G0
    Conserved Domains (4) summary
    COG1390
    Location:443 → 514
    NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
    pfam08788
    Location:337 → 403
    NHR2; NHR2 domain like
    pfam01753
    Location:515 → 551
    zf-MYND; MYND finger
    pfam07531
    Location:122 → 210
    TAFH; NHR1 homology to TAF

  4. XM_006237903.5 → XP_006237965.1  protein CBFA2T1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AB42
    Related
    ENSRNOP00000090913.1
    Conserved Domains (4) summary
    COG1390
    Location:435 → 506
    NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
    pfam08788
    Location:329 → 395
    NHR2; NHR2 domain like
    pfam01753
    Location:507 → 543
    zf-MYND; MYND finger
    pfam07531
    Location:114 → 202
    TAFH; NHR1 homology to TAF

  5. XM_008763548.4 → XP_008761770.2  protein CBFA2T1 isoform X4

    UniProtKB/TrEMBL
    A6II91
    Conserved Domains (4) summary
    COG1390
    Location:406 → 477
    NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
    pfam08788
    Location:300 → 366
    NHR2; NHR2 domain like
    pfam01753
    Location:478 → 514
    zf-MYND; MYND finger
    pfam07531
    Location:85 → 173
    TAFH; NHR1 homology to TAF

  6. XM_039110219.2 → XP_038966147.1  protein CBFA2T1 isoform X5

    Conserved Domains (3) summary
    COG1390
    Location:139 → 210
    NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
    pfam08788
    Location:33 → 99
    NHR2; NHR2 domain like
    pfam01753
    Location:211 → 247
    zf-MYND; MYND finger
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous