Hacd4 3-hydroxyacyl-CoA dehydratase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hacd4provided by RGD
Official Full Name: 3-hydroxyacyl-CoA dehydratase 4provided by RGD
Primary source: RGD:1310339
See related: Ensembl:ENSRNOG00000005772 AllianceGenome:RGD:1310339
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ptplad2; RGD1310339
Summary: Predicted to enable 3-hydroxyacyl-CoA dehydratase activity and enzyme binding activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human HACD4 (3-hydroxyacyl-CoA dehydratase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 82.2), Spleen (RPKM 49.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (107935514..107961271, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (102887597..102915376, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (106728401..106758068, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-hydroxyacyl-CoA dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid elongation	ISO Inferred from Sequence Orthology more info
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4

Names: protein tyrosine phosphatase-like A domain containing 2; protein tyrosine phosphatase-like protein PTPLAD2

NP_001102139.1

EC 4.2.1.134

XP_006238438.1

EC 4.2.1.134

XP_038966193.1

EC 4.2.1.134

XP_063144013.1

EC 4.2.1.134

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108669.1 → NP_001102139.1 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4

See identical proteins and their annotated locations for NP_001102139.1

Status: PROVISIONAL

Source sequence(s)

CH474094

UniProtKB/TrEMBL

A6KRA5

Conserved Domains (1) summary

pfam04387
Location:65 → 222

PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

107935514..107961271 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238376.5 → XP_006238438.1 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform X1

UniProtKB/TrEMBL

A0A8I6AU59

Related

ENSRNOP00000095794.1

Conserved Domains (1) summary

pfam04387
Location:65 → 209

PTPLA; Protein tyrosine phosphatase-like protein, PTPLA
XM_039110265.2 → XP_038966193.1 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform X2

UniProtKB/TrEMBL

D3Z8V6

Related

ENSRNOP00000034988.4

Conserved Domains (1) summary

pfam04387
Location:65 → 206

PTPLA; Protein tyrosine phosphatase-like protein, PTPLA
XM_063287943.1 → XP_063144013.1 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform X3