Lrp8 LDL receptor related protein 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrp8provided by RGD
Official Full Name: LDL receptor related protein 8provided by RGD
Primary source: RGD:1305729
See related: Ensembl:ENSRNOG00000013064 AllianceGenome:RGD:1305729
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables high-density lipoprotein particle binding activity and kinesin binding activity. Involved in several processes, including cellular response to cholesterol; cellular response to growth factor stimulus; and cerebral cortex development. Located in several cellular components, including dendrite; neuronal cell body; and postsynaptic density. Part of microtubule associated complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 86.1), Thymus (RPKM 45.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q34

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (127792236..127864207)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (122563468..122635434)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (127404348..127476636)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that reelin/ApoER2/PSD95 signaling is important for neuronal structure maintenance in mature neurons.
Title: Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons.
total levels of ApoER2 and surface levels of ApoER2 are increased by active Fyn
Title: Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation.
Results highlight a novel relationship between neurotrophins and the reelin-ApoER2 system, suggesting that these two pathways might be linked to regulate brain development, neuronal survival, and some pathological conditions
Title: Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway.
apoER2-mediated uptake of long isoform Sepp1 is responsible for selenium distribution to tissues throughout the body.
Title: Long isoform mouse selenoprotein P (Sepp1) supplies rat myoblast L8 cells with selenium via endocytosis mediated by heparin binding properties and apolipoprotein E receptor-2 (ApoER2).
Fyn, due in part to its effects on Dab1, regulates the phosphorylation, trafficking, and processing of APP and apoEr2.
Title: Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing.
Sertoli cell ApoER2 is a Sepp1 receptor and a component of the selenium delivery pathway to spermatogenic cells
Title: Apolipoprotein E receptor-2 (ApoER2) mediates selenium uptake from selenoprotein P by the mouse testis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle binding	IDA Inferred from Direct Assay more info	PubMed
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables reelin receptor activity	ISO Inferred from Sequence Orthology more info
enables very-low-density lipoprotein particle receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ammon gyrus development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cholesterol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hippocampus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within layer formation in cerebral cortex	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in reelin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in ventral spinal cord development	IBA Inferred from Biological aspect of Ancestor more info
involved_in ventral spinal cord development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in caveola	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: low-density lipoprotein receptor-related protein 8

Names: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427454.1 → NP_001414383.1 low-density lipoprotein receptor-related protein 8 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

127792236..127864207

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238570.4 → XP_006238632.1 low-density lipoprotein receptor-related protein 8 isoform X1

UniProtKB/TrEMBL

A6JYS8

Conserved Domains (7) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:540 → 581

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:426 → 456

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:602 → 642

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:390 → 424

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00104
Location:333 → 369

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039111148.2 → XP_038967076.1 low-density lipoprotein receptor-related protein 8 isoform X2

UniProtKB/TrEMBL

A6JYS8

Conserved Domains (7) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:539 → 580

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:425 → 455

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:332 → 368

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:601 → 641

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:389 → 423

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_006238567.4 → XP_006238629.1 low-density lipoprotein receptor-related protein 8 isoform X8

UniProtKB/TrEMBL

A6JYS8

Conserved Domains (7) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:540 → 581

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:426 → 456

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:602 → 642

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:390 → 424

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00104
Location:333 → 369

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039111149.2 → XP_038967077.1 low-density lipoprotein receptor-related protein 8 isoform X3

UniProtKB/TrEMBL

A6JYS8

Conserved Domains (7) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:527 → 568

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:413 → 443

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:333 → 369

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:589 → 629

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:377 → 411

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_006238571.4 → XP_006238633.1 low-density lipoprotein receptor-related protein 8 isoform X4

UniProtKB/TrEMBL

A6JYS8, D3ZE75

Related

ENSRNOP00000017575.7

Conserved Domains (7) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:526 → 567

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:412 → 442

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:588 → 628

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:376 → 410

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00104
Location:332 → 368

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039111150.2 → XP_038967078.1 low-density lipoprotein receptor-related protein 8 isoform X5

UniProtKB/TrEMBL

A0A8I6ALZ7, A6JYS8

Related

ENSRNOP00000094896.1

Conserved Domains (6) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:499 → 540

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:385 → 415

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:561 → 601

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:349 → 383

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_039111152.2 → XP_038967080.1 low-density lipoprotein receptor-related protein 8 isoform X6

UniProtKB/TrEMBL

A6JYS8

Conserved Domains (6) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:486 → 527

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:372 → 402

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:548 → 588

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:336 → 370

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_003749993.5 → XP_003750041.1 low-density lipoprotein receptor-related protein 8 isoform X7

UniProtKB/TrEMBL

A0A8I5ZTA7, A6JYS8

Related

ENSRNOP00000081536.1

Conserved Domains (6) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:485 → 526

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:371 → 401

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:547 → 587

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:335 → 369

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_039111153.2 → XP_038967081.1 low-density lipoprotein receptor-related protein 8 isoform X9

UniProtKB/TrEMBL

A0A8I6GFL9, A6JYS8

Related

ENSRNOP00000087919.1

Conserved Domains (6) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:499 → 540

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:385 → 415

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:561 → 601

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:349 → 383

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_063287975.1 → XP_063144045.1 low-density lipoprotein receptor-related protein 8 isoform X10
XM_003749992.5 → XP_003750040.1 low-density lipoprotein receptor-related protein 8 isoform X11

UniProtKB/TrEMBL

A6JYS8

Conserved Domains (6) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:485 → 526

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:371 → 401

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:547 → 587

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:335 → 369

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_039111154.2 → XP_038967082.1 low-density lipoprotein receptor-related protein 8 isoform X12

UniProtKB/TrEMBL

A0A8I5ZVL7

Conserved Domains (7) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:413 → 454

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:299 → 329

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:206 → 242

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:475 → 515

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:263 → 297

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_342877.9 → XP_342878.5 low-density lipoprotein receptor-related protein 8 isoform X14

UniProtKB/TrEMBL

A0A8I5ZVL7, A0A8I6GH61

Related

ENSRNOP00000088514.1

Conserved Domains (7) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:400 → 441

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:286 → 316

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:462 → 502

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:250 → 284

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00104
Location:206 → 242

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039111155.2 → XP_038967083.1 low-density lipoprotein receptor-related protein 8 isoform X13

UniProtKB/TrEMBL

A0A8I5ZVL7

Conserved Domains (7) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:412 → 453

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:298 → 328

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:205 → 241

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:474 → 514

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:262 → 296

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_063287977.1 → XP_063144047.1 low-density lipoprotein receptor-related protein 8 isoform X15
XM_039111157.2 → XP_038967085.1 low-density lipoprotein receptor-related protein 8 isoform X17

UniProtKB/TrEMBL

A0A8I5ZVL7

Conserved Domains (6) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:359 → 400

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:245 → 275

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:421 → 461

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:209 → 243

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_039111156.2 → XP_038967084.1 low-density lipoprotein receptor-related protein 8 isoform X16

UniProtKB/TrEMBL

A0A8I5ZVL7

Conserved Domains (6) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:371 → 412

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:257 → 287

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:433 → 473

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:221 → 255

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_039111158.2 → XP_038967086.1 low-density lipoprotein receptor-related protein 8 isoform X18

UniProtKB/TrEMBL

A0A8I5ZVL7

Related

ENSRNOP00000082808.1

Conserved Domains (6) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:358 → 399

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:244 → 274

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:420 → 460

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:208 → 242

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_006238574.4 → XP_006238636.1 low-density lipoprotein receptor-related protein 8 isoform X20

UniProtKB/TrEMBL

A0A8I6A6L0

Related

ENSRNOP00000088471.1

Conserved Domains (6) summary

smart00192
Location:82 → 114

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:358 → 399

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:244 → 274

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:44 → 78

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:420 → 460

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:208 → 242

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_039111160.2 → XP_038967088.1 low-density lipoprotein receptor-related protein 8 isoform X19

Conserved Domains (4) summary

smart00135
Location:160 → 201

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:46 → 85

EGF_CA; Calcium-binding EGF-like domain

pfam00058
Location:222 → 262

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:10 → 44

FXa_inhibition; Coagulation Factor Xa inhibitory site