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Mtf1 metal-regulatory transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362591, updated on 3-Apr-2024

Summary

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Symbol
Mtf1provided by RGD
Full Name
metal-regulatory transcription factor 1provided by RGD
Primary source
RGD:1308956
See related
Ensembl:ENSRNOG00000025724 AllianceGenome:RGD:1308956
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone acetyltransferase binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human MTF1 (metal regulatory transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 40.7), Brain (RPKM 40.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtf1 in Genome Data Viewer
Location:
5q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (142347024..142391810)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (137062319..137107136)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (142797340..142843896)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene splicing factor 3a, subunit 3 Neighboring gene uncharacterized LOC120102976 Neighboring gene inositol polyphosphate-5-phosphatase B Neighboring gene similar to human chromosome 1 open reading frame 122 Neighboring gene yrdC N(6)-threonylcarbamoyltransferase domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke. Valsecchi V, et al. Cell Death Dis, 2021 Apr 30. PMID 33931586, Free PMC Article
  2. The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene. Langmade SJ, et al. J Biol Chem, 2000 Nov 3. PMID 10952993
  3. STAT5 proteins are involved in down-regulation of iron regulatory protein 1 gene expression by nitric oxide. Starzynski RR, et al. Biochem J, 2006 Dec 1. PMID 16886906, Free PMC Article
  4. Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis. Kim JH, et al. Cell, 2014 Feb 13. PMID 24529376
  5. Chromium(VI) inhibits mouse metallothionein-I gene transcription by preventing the zinc-dependent formation of an MTF-1-p300 complex. Kimura T, et al. Biochem J, 2008 Nov 1. PMID 18605988

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke.
    Title: The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cartilage homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to zinc ion ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to cadmium ion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
metal regulatory transcription factor 1
Names
metal regulatory transcription factor 1-like
metal response element binding transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108677.1 → NP_001102147.1  metal regulatory transcription factor 1

    See identical proteins and their annotated locations for NP_001102147.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/TrEMBL
    A6IS54, D3ZBT4
    Related
    ENSRNOP00000031224.4, ENSRNOT00000031928.5
    Conserved Domains (3) summary
    COG5048
    Location:92 → 290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:235 → 252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:244 → 270
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    142347024..142391810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238884.5 → XP_006238946.1  metal regulatory transcription factor 1 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:92 → 290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:235 → 252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:244 → 270
    zf-H2C2_2; Zinc-finger double domain

  2. XM_063288017.1 → XP_063144087.1  metal regulatory transcription factor 1 isoform X2

  3. XM_063288016.1 → XP_063144086.1  metal regulatory transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A6IS54, D3ZBT4

  4. XM_039110342.2 → XP_038966270.1  metal regulatory transcription factor 1 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:81 → 239
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:184 → 201
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_039110343.2 → XP_038966271.1  metal regulatory transcription factor 1 isoform X4

    Conserved Domains (2) summary
    COG5048
    Location:76 → 241
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:174 → 191
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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