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Meaf6 MYST/Esa1-associated factor 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362594, updated on 13-Apr-2024

Summary

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Official Symbol
Meaf6provided by RGD
Official Full Name
MYST/Esa1-associated factor 6provided by RGD
Primary source
RGD:1310440
See related
Ensembl:ENSRNOG00000009309 AllianceGenome:RGD:1310440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310440
Summary
Predicted to be involved in histone acetylation. Predicted to be located in kinetochore. Predicted to be part of histone acetyltransferase complex. Predicted to be active in nucleolus. Orthologous to human MEAF6 (MYST/Esa1 associated factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 78.9), Testes (RPKM 61.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Meaf6 in Genome Data Viewer
Location:
5q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (142628281..142653076)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (137344681..137369703)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (143081298..143103225)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene G protein nucleolar 2 Neighboring gene dynein, axonemal, light intermediate chain 1 Neighboring gene Smad nuclear interacting protein 1 Neighboring gene zinc finger CCCH type containing 12A Neighboring gene transfer RNA proline (anticodon AGG) 51

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Ullah M, et al. Mol Cell Biol, 2008 Nov. PMID 18794358, Free PMC Article
  2. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417
  3. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Ohta S, et al. Cell, 2010 Sep 3. PMID 20813266, Free PMC Article
  4. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Doyon Y, et al. Mol Cell Biol, 2004 Mar. PMID 14966270, Free PMC Article
  5. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Doyon Y, et al. Mol Cell, 2006 Jan 6. PMID 16387653

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
chromatin modification-related protein MEAF6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113784.2 → NP_001107256.1  chromatin modification-related protein MEAF6 isoform 1

    See identical proteins and their annotated locations for NP_001107256.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6IS74, B0BNB4
    Conserved Domains (1) summary
    pfam09340
    Location:18 → 96
    NuA4; Histone acetyltransferase subunit NuA4

  2. NM_001429180.1 → NP_001416109.1  chromatin modification-related protein MEAF6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  3. NM_001429181.1 → NP_001416110.1  chromatin modification-related protein MEAF6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

RNA

  1. NR_190677.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  2. NR_190678.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  3. NR_190679.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  4. NR_190680.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    142628281..142653076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238886.5 → XP_006238948.3  chromatin modification-related protein MEAF6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AMU4

  2. XM_006238887.5 → XP_006238949.3  chromatin modification-related protein MEAF6 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y6F0

RNA

  1. XR_005504489.2 RNA Sequence

  2. XR_592701.4 RNA Sequence

  3. XR_354271.5 RNA Sequence

  4. XR_010066423.1 RNA Sequence

  5. XR_354272.5 RNA Sequence

  6. XR_354273.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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