Ifnlr1 interferon, lambda receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ifnlr1provided by RGD
Official Full Name: interferon, lambda receptor 1provided by RGD
Primary source: RGD:1562689
See related: Ensembl:ENSRNOG00000033984 AllianceGenome:RGD:1562689
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Il28ra; RGD1562689
Summary: Predicted to enable cytokine receptor activity. Predicted to be involved in several processes, including mucosal immune response; positive regulation of cellular respiration; and regulation of defense response to virus by host. Predicted to act upstream of or within defense response to virus. Predicted to be part of interleukin-28 receptor complex. Predicted to be integral component of plasma membrane. Orthologous to human IFNLR1 (interferon lambda receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 21.6), Heart (RPKM 18.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (153203597..153225911)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (147919547..147942328)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (154037243..154058862)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in mucosal immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of interleukin-28 receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interferon lambda receptor 1

Names: interleukin 28 receptor alpha; interleukin-28 receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191868.2 → NP_001178797.1 interferon lambda receptor 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

D3ZB58

Related

ENSRNOP00000048303.4, ENSRNOT00000049459.6

Conserved Domains (1) summary

pfam01108
Location:20 → 109

Tissue_fac; Tissue factor