Spast spastin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spastprovided by RGD
Official Full Name: spastinprovided by RGD
Primary source: RGD:1308494
See related: Ensembl:ENSRNOG00000027136 AllianceGenome:RGD:1308494
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Spg4
Summary: Predicted to enable microtubule-severing ATPase activity and tubulin binding activity. Predicted to be involved in several processes, including axonal transport; microtubule cytoskeleton organization; and protein complex oligomerization. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum tubular network; and nucleus. Predicted to be active in microtubule cytoskeleton. Predicted to colocalize with endoplasmic reticulum; endosome; and midbody. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 91.0), Brain (RPKM 84.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q13

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (26807220..26858456, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (21055349..21106586, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (22230067..22282166, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab3A interacts with spastin to regulate neurite outgrowth in hippocampal neurons.
Title: Rab3A interacts with spastin to regulate neurite outgrowth in hippocampal neurons.
RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin.
Title: RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin.
NA14 may act as an adaptor protein regulating SPG4 localization to centrosomes, temporally and spatially regulating the microtubule-severing activity of SPG4 that is particularly critical during the cell cycle and neuronal development.
Title: Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development.

Submit: New GeneRIF Correction

General gene information

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Markers

RH139397 (e-PCR)
- UniSTS:221483

RH132989 (e-PCR)
- UniSTS:216272

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-tubulin binding	IEA Inferred from Electronic Annotation more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule severing ATPase activity	IEA Inferred from Electronic Annotation more info
enables microtubule severing ATPase activity	ISO Inferred from Sequence Orthology more info
enables microtubule severing ATPase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	IEA Inferred from Electronic Annotation more info
involved_in anterograde axonal transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde axonal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in axonal transport of mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in axonal transport of mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in axonal transport of mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in cytokinetic process	IEA Inferred from Electronic Annotation more info
involved_in cytokinetic process	ISO Inferred from Sequence Orthology more info
involved_in cytokinetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in exit from mitosis	IEA Inferred from Electronic Annotation more info
involved_in exit from mitosis	ISO Inferred from Sequence Orthology more info
involved_in exit from mitosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane fission	IEA Inferred from Electronic Annotation more info
involved_in membrane fission	ISO Inferred from Sequence Orthology more info
involved_in membrane fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule bundle formation	IEA Inferred from Electronic Annotation more info
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in microtubule bundle formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule severing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microtubule severing	ISO Inferred from Sequence Orthology more info
involved_in microtubule severing	ISO Inferred from Sequence Orthology more info
involved_in microtubule severing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle disassembly	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle disassembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear membrane reassembly	IEA Inferred from Electronic Annotation more info
involved_in nuclear membrane reassembly	ISO Inferred from Sequence Orthology more info
involved_in nuclear membrane reassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule depolymerization	IEA Inferred from Electronic Annotation more info
involved_in protein hexamerization	IEA Inferred from Electronic Annotation more info
involved_in protein hexamerization	ISO Inferred from Sequence Orthology more info
involved_in protein hexamerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum tubular network	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: spastin

Names: spastic paraplegia 4 (autosomal dominant; spastic paraplegia 4 (autosomal dominant; spastin)

NP_001102172.2

EC 5.6.1.1

NP_001401883.1

EC 5.6.1.1

XP_008762708.1

EC 5.6.1.1

XP_008762710.1

EC 5.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108702.3 → NP_001102172.2 spastin isoform 2

See identical proteins and their annotated locations for NP_001102172.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

B2RYN7

UniProtKB/TrEMBL

A0A8L2QK18

Related

ENSRNOP00000033763.6, ENSRNOT00000039375.6

Conserved Domains (5) summary

smart00382
Location:339 → 475

AAA; ATPases associated with a variety of cellular activities

cd02679
Location:114 → 192

MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...

pfam00004
Location:343 → 473

AAA; ATPase family associated with various cellular activities (AAA)

pfam09336
Location:545 → 577

Vps4_C; Vps4 C terminal oligomerization domain

cl21455
Location:306 → 362

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001414954.1 → NP_001401883.1 spastin isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2K590

Related

ENSRNOP00000073338.2, ENSRNOT00000079137.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

26807220..26858456 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008764486.4 → XP_008762708.1 spastin isoform X1

UniProtKB/TrEMBL

A0A8L2QK18

Conserved Domains (5) summary

smart00382
Location:372 → 508

AAA; ATPases associated with a variety of cellular activities

cd02679
Location:114 → 193

MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...

pfam00004
Location:376 → 506

AAA; ATPase family associated with various cellular activities (AAA)

pfam09336
Location:578 → 610

Vps4_C; Vps4 C terminal oligomerization domain

cl21455
Location:339 → 395

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_008764488.4 → XP_008762710.1 spastin isoform X2

UniProtKB/TrEMBL

A0A8I6A3R4, A0A8L2QK18

Related

ENSRNOP00000085299.1

Conserved Domains (5) summary

smart00382
Location:340 → 476

AAA; ATPases associated with a variety of cellular activities

cd02679
Location:114 → 193

MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...

pfam00004
Location:344 → 474

AAA; ATPase family associated with various cellular activities (AAA)

pfam09336
Location:546 → 578

Vps4_C; Vps4 C terminal oligomerization domain

cl21455
Location:307 → 363

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases