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Lclat1 lysocardiolipin acyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362702, updated on 11-Apr-2024

Summary

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Official Symbol
Lclat1provided by RGD
Official Full Name
lysocardiolipin acyltransferase 1provided by RGD
Primary source
RGD:1565906
See related
Ensembl:ENSRNOG00000034026 AllianceGenome:RGD:1565906
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lycat; RGD1565906
Summary
Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Predicted to be located in cytosol. Predicted to be active in endoplasmic reticulum. Orthologous to human LCLAT1 (lysocardiolipin acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 55.5), Lung (RPKM 24.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lclat1 in Genome Data Viewer
Location:
6q14
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (27980749..28125076, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (22228933..22373246, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (24377398..24515412)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479330 Neighboring gene uncharacterized LOC102547438 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC100912066 Neighboring gene uncharacterized LOC108351184

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of cardiac mitochondrial monolysocardiolipin acyltransferase activity and expression during development and in fetal alcohol syndrome. Taylor WA, et al. Proc West Pharmacol Soc, 2007. PMID 18605246
  2. Mitochondrial monolysocardiolipin acyltransferase is elevated in the surviving population of H9c2 cardiac myoblast cells exposed to 2-deoxyglucose-induced apoptosis. Danos M, et al. Biochem Cell Biol, 2008 Feb. PMID 18364741
  3. The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids. Zhao Y, et al. J Lipid Res, 2009 May. PMID 19075029, Free PMC Article
  4. Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity. Agarwal AK, et al. Arch Biochem Biophys, 2006 May 15. PMID 16620771
  5. A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse. Cao J, et al. J Biol Chem, 2004 Jul 23. PMID 15152008

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that increased mitochondrial monolysocardiolipin acyltransferase activity, and elevated cardiolipin resynthesis, may be a protective mechanism against monolysocardiolipin-mediated apoptosis.
    Title: Mitochondrial monolysocardiolipin acyltransferase is elevated in the surviving population of H9c2 cardiac myoblast cells exposed to 2-deoxyglucose-induced apoptosis.
  2. cardiac mitochondrial monolysocardiolipin acyltransferase activity declines during postnatal development in the rat and that in utero exposure to alcohol inhibits cardiac monolysocardiolipin acyltransferase
    Title: Regulation of cardiac mitochondrial monolysocardiolipin acyltransferase activity and expression during development and in fetal alcohol syndrome.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysocardiolipin acyltransferase 1
XP_038969005.1
XP_038969006.1
XP_038969007.1
XP_038969009.1
XP_038969010.1
XP_038969011.1
XP_063118810.1
XP_063118811.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    27980749..28125076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039113081.2 → XP_038969009.1  lysocardiolipin acyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AFV0, A6HA05, D3ZFF4
    Conserved Domains (2) summary
    cd07990
    Location:55 → 248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:233 → 306
    Acyltransf_C; Acyltransferase C-terminus

  2. XM_039113082.2 → XP_038969010.1  lysocardiolipin acyltransferase 1 isoform X2

    Conserved Domains (1) summary
    cd07990
    Location:55 → 209
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like

  3. XM_039113078.2 → XP_038969006.1  lysocardiolipin acyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AFV0, A6HA05, D3ZFF4
    Conserved Domains (2) summary
    cd07990
    Location:55 → 248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:233 → 306
    Acyltransf_C; Acyltransferase C-terminus

  4. XM_039113079.2 → XP_038969007.1  lysocardiolipin acyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AFV0, A6HA05, D3ZFF4
    Conserved Domains (2) summary
    cd07990
    Location:55 → 248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:233 → 306
    Acyltransf_C; Acyltransferase C-terminus

  5. XM_063262741.1 → XP_063118811.1  lysocardiolipin acyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A6HA05, D3ZFF4

  6. XM_063262740.1 → XP_063118810.1  lysocardiolipin acyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A6HA05, D3ZFF4

  7. XM_039113083.2 → XP_038969011.1  lysocardiolipin acyltransferase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AFV0
    Conserved Domains (2) summary
    cd07990
    Location:1 → 188
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:173 → 246
    Acyltransf_C; Acyltransferase C-terminus

  8. XM_039113077.2 → XP_038969005.1  lysocardiolipin acyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AFV0, A6HA05, D3ZFF4
    Conserved Domains (2) summary
    cd07990
    Location:55 → 248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:233 → 306
    Acyltransf_C; Acyltransferase C-terminus
Nucleotide Protein Strain
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