Rrm2 ribonucleotide reductase regulatory subunit M2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rrm2provided by RGD
Official Full Name: ribonucleotide reductase regulatory subunit M2provided by RGD
Primary source: RGD:1598310
See related: Ensembl:ENSRNOG00000054286 AllianceGenome:RGD:1598310
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ferric iron binding activity; protein homodimerization activity; and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in mitotic cell cycle; positive regulation of cell population proliferation; and pyrimidine nucleobase metabolic process. Located in nuclear envelope. Used to study endometrial adenocarcinoma. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RRM2 (ribonucleotide reductase regulatory subunit M2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 533.8), Spleen (RPKM 381.5) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (47044755..47075370)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (41339858..41346774)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (43884627..43890818)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RRM2 Improves Cardiomyocyte Proliferation after Myocardial Ischemia Reperfusion Injury through the Hippo-YAP Pathway.
Title: RRM2 Improves Cardiomyocyte Proliferation after Myocardial Ischemia Reperfusion Injury through the Hippo-YAP Pathway.
overexpression of the ribonucleotide reductase (Rrm1 and Rrm2) complex would increase contractility of adult rat cardiomyocytes.
Title: Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC207566P3 (e-PCR)
- UniSTS:271956

RH128375 (e-PCR)
- UniSTS:211683

RH137293 (e-PCR)
- UniSTS:219381

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ferric iron binding	IEA Inferred from Electronic Annotation more info
enables ferric iron binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEA Inferred from Electronic Annotation more info
contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ISO Inferred from Sequence Orthology more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ISO Inferred from Sequence Orthology more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 2'-deoxyribonucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 2'-deoxyribonucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in blastocyst development	IEA Inferred from Electronic Annotation more info
acts_upstream_of blastocyst development	ISO Inferred from Sequence Orthology more info
involved_in deoxyribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in deoxyribonucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in deoxyribonucleotide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within deoxyribonucleotide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein heterotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein heterotetramerization	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleobase metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in ribonucleoside diphosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ribonucleoside diphosphate metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoside-diphosphate reductase complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoside-diphosphate reductase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribonucleoside-diphosphate reductase subunit M2

Names: Ribonucleotide reductase 2; ribonucleotide reductase M2 polypeptide; ribonucleotide reductase small chain; ribonucleotide reductase small subunit

NP_001020911.1

EC 1.17.4.1

XP_038968417.1

EC 1.17.4.1

XP_063118143.1

EC 1.17.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025740.3 → NP_001020911.1 ribonucleoside-diphosphate reductase subunit M2

See identical proteins and their annotated locations for NP_001020911.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q4KLN6

UniProtKB/TrEMBL

A6HAY1

Conserved Domains (1) summary

PLN02492
Location:71 → 390

PLN02492; ribonucleoside-diphosphate reductase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

47044755..47075370

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262073.1 → XP_063118143.1 ribonucleoside-diphosphate reductase subunit M2 isoform X2

UniProtKB/Swiss-Prot

Q4KLN6

UniProtKB/TrEMBL

A6HAY1
XM_039112489.2 → XP_038968417.1 ribonucleoside-diphosphate reductase subunit M2 isoform X1

UniProtKB/TrEMBL

A0A8L2R734

Related

ENSRNOP00000073334.2

Conserved Domains (1) summary

PLN02492
Location:79 → 398

PLN02492; ribonucleoside-diphosphate reductase