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Agmo alkylglycerol monooxygenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 362732, updated on 2-May-2024

Summary

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Official Symbol
Agmoprovided by RGD
Official Full Name
alkylglycerol monooxygenaseprovided by RGD
Primary source
RGD:1312038
See related
Ensembl:ENSRNOG00000023116 AllianceGenome:RGD:1312038
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tmem195; RGD1312038
Summary
Predicted to enable glyceryl-ether monooxygenase activity and iron ion binding activity. Predicted to be involved in ether lipid metabolic process and membrane lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human AGMO (alkylglycerol monooxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 750.5), Thymus (RPKM 42.7) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Agmo in Genome Data Viewer
Location:
6q21
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (59713495..60044851)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (53986236..54317838)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (56846859..57193918)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene mesenchyme homeobox 2 Neighboring gene exosome component 4, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108351227 Neighboring gene uncharacterized LOC108351363

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes. Watschinger K, et al. Proc Natl Acad Sci U S A, 2010 Aug 3. PMID 20643956, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glyceryl-ether monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyceryl-ether monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables glyceryl-ether monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ether lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ether lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alkylglycerol monooxygenase
Names
transmembrane protein 195
NP_001129371.1
XP_038968427.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135899.1 → NP_001129371.1  alkylglycerol monooxygenase

    See identical proteins and their annotated locations for NP_001129371.1

    Status: PROVISIONAL

    Source sequence(s)
    BC127545
    UniProtKB/Swiss-Prot
    A0JPQ8
    UniProtKB/TrEMBL
    A0A8I6GIU1
    Related
    ENSRNOP00000029816.4, ENSRNOT00000032108.6
    Conserved Domains (2) summary
    COG3000
    Location:43 → 276
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
    pfam04116
    Location:119 → 249
    FA_hydroxylase; Fatty acid hydroxylase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    59713495..60044851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112499.2 → XP_038968427.1  alkylglycerol monooxygenase isoform X1

    UniProtKB/TrEMBL
    A0A8I6GIU1
    Conserved Domains (1) summary
    COG3000
    Location:43 → 276
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JPQ8.1 GenPept UniProtKB/Swiss-Prot:A0JPQ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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