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Vrk1 VRK serine/threonine kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362779, updated on 2-May-2024

Summary

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Official Symbol
Vrk1provided by RGD
Official Full Name
VRK serine/threonine kinase 1provided by RGD
Primary source
RGD:1306069
See related
Ensembl:ENSRNOG00000005274 AllianceGenome:RGD:1306069
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable histone kinase activity; nucleosomal histone binding activity; and protein kinase binding activity. Predicted to be involved in Golgi disassembly; histone H3-S10 phosphorylation; and histone H3-T3 phosphorylation. Predicted to act upstream of or within protein autophosphorylation. Predicted to be located in Golgi stack; cytosol; and nuclear lumen. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 248.1), Spleen (RPKM 157.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (130679400..130746089)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (124914770..124981508)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (129835788..129902839)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103616 Neighboring gene uncharacterized LOC134479472 Neighboring gene uncharacterized LOC134479293 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NMR solution structure of human vaccinia-related kinase 1 (VRK1) reveals the C-terminal tail essential for its structural stability and autocatalytic activity. Shin J, et al. J Biol Chem, 2011 Jun 24. PMID 21543316, Free PMC Article
  2. Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation. López-Sánchez I, et al. Mol Cell Biol, 2009 Mar. PMID 19103756, Free PMC Article
  3. Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells. Kang TH, et al. Mol Cell Biol, 2007 Dec. PMID 17938195, Free PMC Article
  4. Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase. Kim W, et al. J Biol Chem, 2012 Feb 17. PMID 22194607, Free PMC Article
  5. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. Nichols RJ, et al. J Biol Chem, 2004 Feb 27. PMID 14645249

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings collectively support a role of VRK1 as a novel mitotic histone H3 kinase in mammals.
    Title: Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AX kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3S10 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3T3 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleosomal DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Cajal body organization ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase VRK1
Names
vaccinia related kinase 1
NP_001012194.1
XP_006240592.1
XP_006240593.1
XP_006240594.1
XP_038968462.1
XP_038968463.1
XP_038968464.1
XP_038968465.1
XP_038968466.1
XP_038968468.1
XP_038968469.1
XP_038968471.1
XP_063118199.1
XP_063118200.1
XP_063118201.1
XP_063118202.1
XP_063118203.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012194.1 → NP_001012194.1  serine/threonine-protein kinase VRK1

    See identical proteins and their annotated locations for NP_001012194.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079130
    UniProtKB/TrEMBL
    A0A8I6AIR3, Q6AYA2
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    130679400..130746089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112534.2 → XP_038968462.1  serine/threonine-protein kinase VRK1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIR3, Q6AYA2
    Related
    ENSRNOP00000093032.1
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  2. XM_006240532.5 → XP_006240594.1  serine/threonine-protein kinase VRK1 isoform X1

    See identical proteins and their annotated locations for XP_006240594.1

    UniProtKB/TrEMBL
    A0A8I6AIR3, Q6AYA2
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  3. XM_006240530.5 → XP_006240592.1  serine/threonine-protein kinase VRK1 isoform X1

    See identical proteins and their annotated locations for XP_006240592.1

    UniProtKB/TrEMBL
    A0A8I6AIR3, Q6AYA2
    Related
    ENSRNOP00000029546.5
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  4. XM_039112543.2 → XP_038968471.1  serine/threonine-protein kinase VRK1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AIR3
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  5. XM_039112540.2 → XP_038968468.1  serine/threonine-protein kinase VRK1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIR3, Q6AYA2
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  6. XM_063262131.1 → XP_063118201.1  serine/threonine-protein kinase VRK1 isoform X2

  7. XM_063262130.1 → XP_063118200.1  serine/threonine-protein kinase VRK1 isoform X2

  8. XM_006240531.5 → XP_006240593.1  serine/threonine-protein kinase VRK1 isoform X1

    See identical proteins and their annotated locations for XP_006240593.1

    UniProtKB/TrEMBL
    A0A8I6AIR3, Q6AYA2
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  9. XM_063262132.1 → XP_063118202.1  serine/threonine-protein kinase VRK1 isoform X2

  10. XM_039112538.2 → XP_038968466.1  serine/threonine-protein kinase VRK1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIR3, Q6AYA2
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  11. XM_063262129.1 → XP_063118199.1  serine/threonine-protein kinase VRK1 isoform X1

    UniProtKB/TrEMBL
    Q6AYA2

  12. XM_063262133.1 → XP_063118203.1  serine/threonine-protein kinase VRK1 isoform X1

    UniProtKB/TrEMBL
    Q6AYA2

  13. XM_039112535.2 → XP_038968463.1  serine/threonine-protein kinase VRK1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIR3, Q6AYA2
    Related
    ENSRNOP00000084211.1
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  14. XM_039112536.2 → XP_038968464.1  serine/threonine-protein kinase VRK1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIR3, Q6AYA2
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  15. XM_039112537.2 → XP_038968465.1  serine/threonine-protein kinase VRK1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIR3, Q6AYA2
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  16. XM_039112541.2 → XP_038968469.1  serine/threonine-protein kinase VRK1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIR3, Q6AYA2
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
Nucleotide Protein Strain
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