Dot1l DOT1 like histone lysine methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dot1lprovided by RGD
Official Full Name: DOT1 like histone lysine methyltransferaseprovided by RGD
Primary source: RGD:1306644
See related: Ensembl:ENSRNOG00000032546 AllianceGenome:RGD:1306644
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable histone methyltransferase activity (H3-K79 specific). Predicted to be involved in several processes, including DNA damage checkpoint signaling; regulation of receptor signaling pathway via JAK-STAT; and subtelomeric heterochromatin assembly. Predicted to act upstream of or within with a negative effect on gene expression. Predicted to act upstream of or within histone H3-K79 methylation; positive regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in mixed phenotype acute leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 51.8), Adrenal (RPKM 43.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (9569439..9607095, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8918764..8959474, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (11786105..11824742, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nullifying epigenetic writer DOT1L attenuates neointimal hyperplasia.
Title: Nullifying epigenetic writer DOT1L attenuates neointimal hyperplasia.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127906 (e-PCR)
- UniSTS:211216

RH134554 (e-PCR)
- UniSTS:217834

AW907654 (e-PCR)
- UniSTS:185844

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables histone H3K79 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K79 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within_negative_effect gene expression	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription regulatory region DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase, H3 lysine-79 specific

Names: DOT1-like histone H3K79 methyltransferase; DOT1-like, histone H3 methyltransferase

NP_001102203.2

EC 2.1.1.354

XP_006241021.1

EC 2.1.1.354

XP_038935320.1

EC 2.1.1.354

XP_063119812.1

EC 2.1.1.354

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108733.2 → NP_001102203.2 histone-lysine N-methyltransferase, H3 lysine-79 specific

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6K8G9, D3ZCP0

Related

ENSRNOP00000043691.4, ENSRNOT00000051467.5

Conserved Domains (3) summary

pfam08123
Location:115 → 317

DOT1; Histone methylation protein DOT1

PHA03307
Location:784 → 1125

PHA03307; transcriptional regulator ICP4; Provisional

TIGR04523
Location:506 → 659

Mplasa_alph_rch; helix-rich Mycoplasma protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

9569439..9607095 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240959.4 → XP_006241021.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1

See identical proteins and their annotated locations for XP_006241021.1

UniProtKB/TrEMBL

A0A8I5ZRT2, A6K8H0

Related

ENSRNOP00000081362.1

Conserved Domains (3) summary

pfam08123
Location:115 → 317

DOT1; Histone methylation protein DOT1

pfam12474
Location:535 → 652

PKK; Polo kinase kinase

pfam15035
Location:491 → 659

Rootletin; Ciliary rootlet component, centrosome cohesion
XM_039079392.2 → XP_038935320.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2

UniProtKB/TrEMBL

A6K8H0

Conserved Domains (4) summary

pfam08123
Location:112 → 314

DOT1; Histone methylation protein DOT1

PHA03307
Location:781 → 1122

PHA03307; transcriptional regulator ICP4; Provisional

TIGR04523
Location:503 → 656

Mplasa_alph_rch; helix-rich Mycoplasma protein

cd20902
Location:478 → 542

CC_DOT1L; coiled coil domain of disruptor of telomeric-silencing 1-like (DOT1L) and similar proteins
XM_063263742.1 → XP_063119812.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X3