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Mtss1 MTSS I-BAR domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362918, updated on 11-Apr-2024

Summary

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Official Symbol
Mtss1provided by RGD
Official Full Name
MTSS I-BAR domain containing 1provided by RGD
Primary source
RGD:1309883
See related
Ensembl:ENSRNOG00000009001 AllianceGenome:RGD:1309883
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including actin binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including adherens junction maintenance; positive regulation of actin filament bundle assembly; and urogenital system development. Predicted to act upstream of or within several processes, including actin filament polymerization; bone mineralization; and magnesium ion homeostasis. Predicted to be located in adherens junction and cytoplasm. Predicted to be active in actin cytoskeleton. Predicted to be intrinsic component of the cytoplasmic side of the plasma membrane. Orthologous to human MTSS1 (MTSS I-BAR domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 251.7), Heart (RPKM 218.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q33
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (92378228..92517444, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (90488751..90628007, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (98820799..98960878, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 139 Neighboring gene TatD DNase domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene uncharacterized LOC120093662 Neighboring gene uncharacterized LOC134479913 Neighboring gene uncharacterized LOC134479912 Neighboring gene uncharacterized LOC134479604 Neighboring gene uncharacterized LOC134479915

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Proteome analysis of actin filament-associated proteins in the postnatal rat cerebellum. Shi N, et al. Neuroscience, 2012 Dec 27. PMID 23032931
  2. Structural basis for the actin-binding function of missing-in-metastasis. Lee SH, et al. Structure, 2007 Feb. PMID 17292833, Free PMC Article
  3. MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta. Woodings JA, et al. Biochem J, 2003 Apr 15. PMID 12570871, Free PMC Article
  4. Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain. Mattila PK, et al. J Biol Chem, 2003 Mar 7. PMID 12482861
  5. A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. Yamagishi A, et al. J Biol Chem, 2004 Apr 9. PMID 14752106

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in adherens junction maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adherens junction maintenance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within bone mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to fluid shear stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in epithelial cell proliferation involved in renal tubule morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell proliferation involved in renal tubule morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glomerulus morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in glomerulus morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within magnesium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metanephric tubule development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nephron tubule epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in nephron tubule epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in plasma membrane organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in renal tubule morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in renal tubule morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein MTSS 1
Names
MTSS1, I-BAR domain containing
metastasis suppressor 1
metastasis suppressor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130563.1 → NP_001124035.1  protein MTSS 1

    See identical proteins and their annotated locations for NP_001124035.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    A6HRL5, A6HRL7, D3ZYM5
    Related
    ENSRNOP00000011984.4, ENSRNOT00000011984.6
    Conserved Domains (1) summary
    cd07643
    Location:38 → 272
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    92378228..92517444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263852.1 → XP_063119922.1  protein MTSS 1 isoform X12

  2. XM_063263849.1 → XP_063119919.1  protein MTSS 1 isoform X8

  3. XM_063263846.1 → XP_063119916.1  protein MTSS 1 isoform X4

  4. XM_017594956.3 → XP_017450445.1  protein MTSS 1 isoform X3

    UniProtKB/TrEMBL
    A6HRL7

  5. XM_063263853.1 → XP_063119923.1  protein MTSS 1 isoform X13

  6. XM_063263848.1 → XP_063119918.1  protein MTSS 1 isoform X7

  7. XM_063263847.1 → XP_063119917.1  protein MTSS 1 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K2D5

  8. XM_017594957.3 → XP_017450446.1  protein MTSS 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AFD6, A6HRL7
    Related
    ENSRNOP00000086949.1

  9. XM_017594954.3 → XP_017450443.1  protein MTSS 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AWT9, A6HRL7
    Related
    ENSRNOP00000093281.1

  10. XM_039079520.2 → XP_038935448.1  protein MTSS 1 isoform X1

    UniProtKB/TrEMBL
    A6HRL7
    Conserved Domains (4) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:335 → 737
    PHA03247; large tegument protein UL36; Provisional
    PTZ00441
    Location:620 → 768
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    cd22060
    Location:739 → 769
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

  11. XM_039079525.2 → XP_038935453.1  protein MTSS 1 isoform X9

    UniProtKB/TrEMBL
    A0A8I6AN35, A6HRL7
    Related
    ENSRNOP00000097050.1
    Conserved Domains (3) summary
    cd07643
    Location:7 → 237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PTZ00441
    Location:540 → 688
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    cd22060
    Location:659 → 689
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

  12. XM_063263850.1 → XP_063119920.1  protein MTSS 1 isoform X10

  13. XM_063263851.1 → XP_063119921.1  protein MTSS 1 isoform X11

Nucleotide Protein Strain
Heading Accession and Version

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