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Parvb parvin, beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 362973, updated on 11-Apr-2024

Summary

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Official Symbol
Parvbprovided by RGD
Official Full Name
parvin, betaprovided by RGD
Primary source
RGD:1311485
See related
Ensembl:ENSRNOG00000055305 AllianceGenome:RGD:1311485
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin binding activity. Predicted to be involved in several processes, including actin cytoskeleton reorganization; lamellipodium assembly; and substrate adhesion-dependent cell spreading. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including actin cytoskeleton; focal adhesion; and lamellipodium. Orthologous to human PARVB (parvin beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 182.1), Muscle (RPKM 137.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Parvb in Genome Data Viewer
Location:
7q34
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (117240238..117325744)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (115360254..115445767)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (125189827..125275977)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479759 Neighboring gene SAMM50 sorting and assembly machinery component Neighboring gene small nucleolar RNA SNORA48 Neighboring gene parvin, gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. α-Parvin and β-parvin in the rat uterus during decidualisation and uterine receptivity. Nicholson L, et al. Histochem Cell Biol, 2019 May. PMID 30515554
  2. The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor. Mishima W, et al. Genes Cells, 2004 Mar. PMID 15005707
  3. Structural basis for paxillin binding and focal adhesion targeting of β-parvin. Stiegler AL, et al. J Biol Chem, 2012 Sep 21. PMID 22869380, Free PMC Article
  4. ILK, PINCH and parvin: the tIPP of integrin signalling. Legate KR, et al. Nat Rev Mol Cell Biol, 2006 Jan. PMID 16493410
  5. Affixin activates Rac1 via betaPIX in C2C12 myoblast. Matsuda C, et al. FEBS Lett, 2008 Apr 9. PMID 18325335

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell projection assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity regulating cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
beta-parvin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134780.1 → NP_001128252.1  beta-parvin

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2KB09, A0A8I5Y6N4
    Related
    ENSRNOP00000075605.1, ENSRNOT00000080152.2
    Conserved Domains (1) summary
    pfam00307
    Location:89 → 190
    CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    117240238..117325744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079611.2 → XP_038935539.1  beta-parvin isoform X2

    UniProtKB/TrEMBL
    A0A8I6AS53
    Conserved Domains (2) summary
    cd21336
    Location:51 → 156
    CH_PARVB_rpt1; first calponin homology (CH) domain found in beta-parvin
    cl00030
    Location:198 → 327
    CH_SF; calponin homology (CH) domain superfamily

  2. XM_039079610.2 → XP_038935538.1  beta-parvin isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZR23, A0A8I6AS53
    Related
    ENSRNOP00000080773.1
    Conserved Domains (2) summary
    cd21336
    Location:61 → 166
    CH_PARVB_rpt1; first calponin homology (CH) domain found in beta-parvin
    cl00030
    Location:208 → 337
    CH_SF; calponin homology (CH) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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