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Cpne8 copine 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362988, updated on 3-Apr-2024

Summary

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Official Symbol
Cpne8provided by RGD
Official Full Name
copine 8provided by RGD
Primary source
RGD:1307939
See related
Ensembl:ENSRNOG00000026128 AllianceGenome:RGD:1307939
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium-dependent phospholipid binding activity. Predicted to be involved in cellular response to calcium ion. Predicted to be active in plasma membrane. Orthologous to human CPNE8 (copine 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 49.3), Heart (RPKM 38.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q35
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (123494864..123669060, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (121615293..121789507, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (131623180..131798236, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093709 Neighboring gene ALG10, alpha-1,2-glucosyltransferase Neighboring gene uncharacterized LOC134479767 Neighboring gene 40S ribosomal protein S19 pseudogene Neighboring gene pyruvate kinase M1/2, pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
copine-8
Names
copine 8 protein
copine VIII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108750.1 → NP_001102220.1  copine-8

    See identical proteins and their annotated locations for NP_001102220.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474027
    UniProtKB/TrEMBL
    A0A8I6GJF1, B5DEX3, F7EN58
    Related
    ENSRNOP00000037093.4, ENSRNOT00000039857.5
    Conserved Domains (3) summary
    cd04047
    Location:171 → 282
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:37 → 158
    C2A_Copine; C2 domain first repeat in Copine
    cd01459
    Location:292 → 548
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    123494864..123669060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263951.1 → XP_063120021.1  copine-8 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZKW9, A6K7P9

  2. XM_039079639.2 → XP_038935567.1  copine-8 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GJF1

  3. XM_063263950.1 → XP_063120020.1  copine-8 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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