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Pgm3 phosphoglucomutase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363109, updated on 13-Apr-2024

Summary

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Official Symbol
Pgm3provided by RGD
Official Full Name
phosphoglucomutase 3provided by RGD
Primary source
RGD:1305221
See related
Ensembl:ENSRNOG00000009515 AllianceGenome:RGD:1305221
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphoacetylglucosamine mutase activity and phosphoglucomutase activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process; hemopoiesis; and protein glycosylation. Predicted to act upstream of or within glucose 1-phosphate metabolic process and spermatogenesis. Human ortholog(s) of this gene implicated in immunodeficiency 23 and teratoma. Orthologous to human PGM3 (phosphoglucomutase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 100.0), Brain (RPKM 71.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pgm3 in Genome Data Viewer
Location:
8q31
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (96398331..96416045, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (87518317..87536021, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (94225513..94243230, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ubiquitin protein ligase E3D Neighboring gene stathmin-like Neighboring gene DOP1 leucine zipper like protein A Neighboring gene RWD domain containing 2A Neighboring gene malic enzyme 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment. Zhang Y, et al. J Allergy Clin Immunol, 2014 May. PMID 24589341, Free PMC Article
  2. Gene loss in human teratomas. Linder D. Proc Natl Acad Sci U S A, 1969 Jul. PMID 5259759, Free PMC Article
  3. Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Greig KT, et al. Mol Cell Biol, 2007 Aug. PMID 17548465, Free PMC Article
  4. Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis. Mio T, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 11004509
  5. Isoenzymes of hexokinase, 6-phosphogluconate dehydrogenase, phosphoglucomutase and lactate dehydrogenase in uterine cancer. Marshall MJ, et al. Br J Cancer, 1979 Sep. PMID 508567, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoacetylglucosamine mutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoacetylglucosamine mutase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-N-acetylglucosamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within UDP-N-acetylglucosamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UDP-N-acetylglucosamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hemopoiesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphoacetylglucosamine mutase
NP_001388122.1
XP_008764673.1
XP_063121858.1
XP_063121859.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401193.1 → NP_001388122.1  phosphoacetylglucosamine mutase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A9K3Y705, B2RYN0, D3ZFX4
    Related
    ENSRNOP00000062246.2, ENSRNOT00000067699.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    96398331..96416045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265788.1 → XP_063121858.1  phosphoacetylglucosamine mutase isoform X1

    UniProtKB/TrEMBL
    A6I1U8

  2. XM_063265789.1 → XP_063121859.1  phosphoacetylglucosamine mutase isoform X2

    UniProtKB/TrEMBL
    A0A9K3Y705, B2RYN0, D3ZFX4

  3. XM_008766451.4 → XP_008764673.1  phosphoacetylglucosamine mutase isoform X1

    See identical proteins and their annotated locations for XP_008764673.1

    UniProtKB/TrEMBL
    A6I1U8, A6I1U9
    Conserved Domains (2) summary
    cd03086
    Location:22 → 525
    PGM3; PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into ...
    PLN02895
    Location:1 → 523
    PLN02895; phosphoacetylglucosamine mutase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108772.1: Suppressed sequence

    Description
    NM_001108772.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version

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