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Cenpq centromere protein Q [ Rattus norvegicus (Norway rat) ]

Gene ID: 363198, updated on 13-Apr-2024

Summary

Official Symbol
Cenpqprovided by RGD
Official Full Name
centromere protein Qprovided by RGD
Primary source
RGD:1359451
See related
Ensembl:ENSRNOG00000056226 AllianceGenome:RGD:1359451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in metaphase plate congression and positive regulation of protein localization to kinetochore. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be part of Mis6-Sim4 complex. Predicted to be active in nucleus. Orthologous to human CENPQ (centromere protein Q). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 65.0), Thymus (RPKM 45.7) and 9 other tissues See more
Orthologs
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Genomic context

See Cenpq in Genome Data Viewer
Location:
9q13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (27454339..27469371)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (19957122..19972807)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (23352271..23368774)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094642 Neighboring gene methylmalonyl-CoA mutase Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene glycine-N-acyltransferase-like 3 Neighboring gene similar to human chromosome 6 open reading frame 141

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in metaphase chromosome alignment IEA
Inferred from Electronic Annotation
more info
 
involved_in metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
 
involved_in metaphase chromosome alignment ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein localization to kinetochore IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
part_of inner kinetochore IEA
Inferred from Electronic Annotation
more info
 
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
centromere protein Q
Names
CENP-Q

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014215.2NP_001014237.1  centromere protein Q isoform 2

    See identical proteins and their annotated locations for NP_001014237.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q66H02
    UniProtKB/TrEMBL
    A0A8I5ZZW1
    Related
    ENSRNOP00000072803.2, ENSRNOT00000081459.2
    Conserved Domains (1) summary
    pfam13094
    Location:119268
    CENP-Q; a CENPA-CAD centromere complex subunit
  2. NM_001419500.1NP_001406429.1  centromere protein Q isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    Related
    ENSRNOP00000084774.1, ENSRNOT00000104636.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    27454339..27469371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)