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Cops7b COP9 signalosome subunit 7B [ Rattus norvegicus (Norway rat) ]

Gene ID: 363273, updated on 30-Mar-2024

Summary

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Official Symbol
Cops7bprovided by RGD
Official Full Name
COP9 signalosome subunit 7Bprovided by RGD
Primary source
RGD:1306918
See related
Ensembl:ENSRNOG00000018723 AllianceGenome:RGD:1306918
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in protein deneddylation. Predicted to be located in nucleoplasm. Predicted to be part of COP9 signalosome. Orthologous to human COPS7B (COP9 signalosome subunit 7B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 43.2), Spleen (RPKM 34.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
9q35
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (94686314..94711903)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (87238132..87263967)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (93607199..93633064)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene phosphodiesterase 6D Neighboring gene transfer RNA valine (anticodon AAC) 37 Neighboring gene uncharacterized LOC134480604 Neighboring gene uncharacterized LOC134480605 Neighboring gene natriuretic peptide C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Sharon M, et al. Structure, 2009 Jan 14. PMID 19141280
  2. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. Fang L, et al. J Proteome Res, 2008 Nov. PMID 18850735, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in COP9 signalosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deneddylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 7b
Names
COP9 (constitutive photomorphogenic) homolog, subunit 7b
COP9 constitutive photomorphogenic homolog subunit 7B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108807.2 → NP_001102277.1  COP9 signalosome complex subunit 7b

    See identical proteins and their annotated locations for NP_001102277.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A6JWJ3, D3ZU52
    Related
    ENSRNOP00000025411.4, ENSRNOT00000025411.7
    Conserved Domains (1) summary
    smart00753
    Location:146 → 235
    PAM; PCI/PINT associated module

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    94686314..94711903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083916.2 → XP_038939844.1  COP9 signalosome complex subunit 7b isoform X2

    UniProtKB/TrEMBL
    A6JWJ5
    Conserved Domains (2) summary
    smart00088
    Location:88 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  2. XM_006245414.5 → XP_006245476.1  COP9 signalosome complex subunit 7b isoform X1

    See identical proteins and their annotated locations for XP_006245476.1

    UniProtKB/TrEMBL
    A6JWJ3, D3ZU52
    Conserved Domains (1) summary
    smart00753
    Location:146 → 235
    PAM; PCI/PINT associated module
Nucleotide Protein Strain
Heading Accession and Version

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