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Tspan7 tetraspanin 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363447, updated on 2-May-2024

Summary

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Official Symbol
Tspan7provided by RGD
Official Full Name
tetraspanin 7provided by RGD
Primary source
RGD:1589725
See related
Ensembl:ENSRNOG00000003229 AllianceGenome:RGD:1589725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
A15; MXS1; Tm4sf2; TALLA-1; DXS1692E
Summary
Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 58. Orthologous to human TSPAN7 (tetraspanin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 1674.6), Lung (RPKM 1213.9) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tspan7 in Genome Data Viewer
Location:
Xq12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (14881327..14978627, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (12208783..12306092, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (13261551..13282886, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484143 Neighboring gene uncharacterized LOC120099251 Neighboring gene MID1 interacting protein 1 Neighboring gene elongation factor 1-gamma pseudogene Neighboring gene U2 spliceosomal RNA Neighboring gene RIKEN cDNA 4933416E14 gene like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats. Pang S, et al. Life Sci Alliance, 2023 Mar. PMID 36625203, Free PMC Article
  2. The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking. Bassani S, et al. Neuron, 2012 Mar 22. PMID 22445342, Free PMC Article
  3. Functional identification of neuroprotective molecules. Dai C, et al. PLoS One, 2010 Nov 24. PMID 21124846, Free PMC Article
  4. Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes. Kuroiwa A, et al. Cytogenet Cell Genet, 1998. PMID 9730605
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Integrin beta1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats.
    Title: Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tetraspanin-7
Names
Transmembrane 4, superfamily member 2 (cell surface glycoprotein A15)
neuroprotective protein 5
transmembrane 4 superfamily member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398737.1 → NP_001385666.1  tetraspanin-7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A9K3Y7X8, B0BNE7, F1M9I6
    Related
    ENSRNOP00000057580.5, ENSRNOT00000060857.6
    Conserved Domains (2) summary
    cd03161
    Location:110 → 213
    TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:15 → 237
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    14881327..14978627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108815.1: Suppressed sequence

    Description
    NM_001108815.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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