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Piga phosphatidylinositol glycan anchor biosynthesis, class A [ Rattus norvegicus (Norway rat) ]

Gene ID: 363464, updated on 13-Apr-2024

Summary

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Official Symbol
Pigaprovided by RGD
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Aprovided by RGD
Primary source
RGD:1589723
See related
Ensembl:ENSRNOG00000003554 AllianceGenome:RGD:1589723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 2 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGA (phosphatidylinositol glycan anchor biosynthesis class A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 44.6), Kidney (RPKM 41.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq14
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (33672832..33687747, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (30043033..30055861, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (31786823..31799751, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 9 Neighboring gene ankyrin repeat and SOCS box containing 11 Neighboring gene vascular endothelial growth factor D Neighboring gene ubiquitin-conjugating enzyme E2 K pseudogene Neighboring gene pirin Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular analysis of GPI-anchor biosynthesis pathway genes in rat strains used for the Pig-a gene mutation assay. Dad A, et al. Mutat Res Genet Toxicol Environ Mutagen, 2020 Oct-Dec. PMID 33198937
  2. Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa. Labash C, et al. Mutat Res Genet Toxicol Environ Mutagen, 2015 Apr. PMID 25868128, Free PMC Article
  3. Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using pig-a mutation and reticulocyte micronucleus assays. Avlasevich SL, et al. Environ Mol Mutagen, 2014 Jun. PMID 24574022
  4. Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone. Dertinger SD, et al. Environ Mol Mutagen, 2014 May. PMID 24449360
  5. Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds. Dertinger SD, et al. Toxicol Sci, 2012 Dec. PMID 22923490, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular analysis of GPI-anchor biosynthesis pathway genes in rat strains used for the Pig-a gene mutation assay.
    Title: Molecular analysis of GPI-anchor biosynthesis pathway genes in rat strains used for the Pig-a gene mutation assay.
  2. Data suggest the use of both sexes for phosphatidylinositolglycan class A protein Pig-a gene mutation studies.
    Title: Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa.
  3. Pig-a mutation is associated with diethylnitrosamine genotoxicity.
    Title: Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using pig-a mutation and reticulocyte micronucleus assays.
  4. Pig-a gene mutation is associated with micronucleated reticulocyte induction.
    Title: Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.
  5. Data demonstrate the value of integrating Pig-a mutation and micronucleus endpoints into in vivo toxicology studies.
    Title: Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylinositol N-acetylglucosaminyltransferase subunit A
Names
N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein
phosphatidylinositol glycan, class A
NP_001102286.1
NP_001387965.1
XP_006256932.1
XP_006256935.1
XP_006256938.1
XP_038955802.1
XP_038955803.1
XP_038955804.1
XP_038955807.1
XP_038955808.1
XP_038955811.1
XP_038955813.1
XP_038955814.1
XP_038955816.1
XP_038955817.1
XP_063136197.1
XP_063136198.1
XP_063136199.1
XP_063136200.1
XP_063136201.1
XP_063136202.1
XP_063136203.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108816.2 → NP_001102286.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform 2

    See identical proteins and their annotated locations for NP_001102286.1

    Status: VALIDATED

    Source sequence(s)
    CH474014
    UniProtKB/TrEMBL
    A6K2K6
    Conserved Domains (1) summary
    cl10013
    Location:5 → 200
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

  2. NM_001401036.1 → NP_001387965.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    D4AAY7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    33672832..33687747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099876.2 → XP_038955804.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

    UniProtKB/TrEMBL
    D4AAY7
    Conserved Domains (1) summary
    cd03796
    Location:34 → 433
    GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

  2. XM_063280129.1 → XP_063136199.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

    UniProtKB/TrEMBL
    D4AAY7

  3. XM_039099874.2 → XP_038955802.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

    UniProtKB/TrEMBL
    D4AAY7
    Related
    ENSRNOP00000045342.4
    Conserved Domains (1) summary
    cd03796
    Location:34 → 433
    GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

  4. XM_063280128.1 → XP_063136198.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

    UniProtKB/TrEMBL
    D4AAY7

  5. XM_063280133.1 → XP_063136203.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X5

    UniProtKB/TrEMBL
    A6K2K6

  6. XM_063280132.1 → XP_063136202.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X4

  7. XM_039099886.2 → XP_038955814.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X5

    UniProtKB/TrEMBL
    A6K2K6
    Conserved Domains (1) summary
    cl10013
    Location:5 → 200
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

  8. XM_006256873.5 → XP_006256935.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

    See identical proteins and their annotated locations for XP_006256935.1

    UniProtKB/TrEMBL
    D4AAY7
    Conserved Domains (1) summary
    cd03796
    Location:34 → 433
    GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

  9. XM_039099888.2 → XP_038955816.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X5

    UniProtKB/TrEMBL
    A6K2K6
    Conserved Domains (1) summary
    cl10013
    Location:5 → 200
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

  10. XM_039099879.2 → XP_038955807.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

    UniProtKB/TrEMBL
    D4AAY7
    Conserved Domains (1) summary
    cd03796
    Location:34 → 433
    GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

  11. XM_039099875.2 → XP_038955803.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

    UniProtKB/TrEMBL
    D4AAY7
    Conserved Domains (1) summary
    cd03796
    Location:34 → 433
    GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

  12. XM_006256876.3 → XP_006256938.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

    See identical proteins and their annotated locations for XP_006256938.1

    UniProtKB/TrEMBL
    D4AAY7
    Conserved Domains (1) summary
    cd03796
    Location:34 → 433
    GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

  13. XM_039099889.2 → XP_038955817.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X5

    UniProtKB/TrEMBL
    A6K2K6
    Conserved Domains (1) summary
    cl10013
    Location:5 → 200
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

  14. XM_063280127.1 → XP_063136197.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

    UniProtKB/TrEMBL
    D4AAY7

  15. XM_006256870.4 → XP_006256932.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

    See identical proteins and their annotated locations for XP_006256932.1

    UniProtKB/TrEMBL
    D4AAY7
    Conserved Domains (1) summary
    cd03796
    Location:34 → 433
    GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

  16. XM_039099880.2 → XP_038955808.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

    UniProtKB/TrEMBL
    D4AAY7
    Conserved Domains (1) summary
    cd03796
    Location:34 → 433
    GT4_PIG-A-like; phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins

  17. XM_039099885.2 → XP_038955813.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X4

    Conserved Domains (1) summary
    cl10013
    Location:12 → 208
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

  18. XM_039099883.2 → XP_038955811.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X4

    Conserved Domains (1) summary
    cl10013
    Location:12 → 208
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

  19. XM_063280130.1 → XP_063136200.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X2

  20. XM_063280131.1 → XP_063136201.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X3

    UniProtKB/TrEMBL
    A0A8I6AMH9

RNA

  1. XR_005498009.2 RNA Sequence

  2. XR_005498007.2 RNA Sequence

  3. XR_005498010.2 RNA Sequence

  4. XR_005498008.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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