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Bcas3 BCAS3, microtubule associated cell migration factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 363662, updated on 13-Apr-2024

Summary

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Official Symbol
Bcas3provided by RGD
Official Full Name
BCAS3, microtubule associated cell migration factorprovided by RGD
Primary source
RGD:1560788
See related
Ensembl:ENSRNOG00000066893 AllianceGenome:RGD:1560788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560788
Summary
Predicted to enable several functions, including acetyltransferase activator activity; beta-tubulin binding activity; and histone acetyltransferase binding activity. Predicted to be involved in several processes, including cellular response to estrogen stimulus; positive regulation of cellular component organization; and regulation of GTPase activity. Predicted to be located in several cellular components, including cytoskeleton; phagophore assembly site; and transcriptionally active chromatin. Orthologous to human BCAS3 (BCAS3 microtubule associated cell migration factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 116.5), Kidney (RPKM 83.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bcas3 in Genome Data Viewer
Location:
10q26
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70711084..71170492)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (70213710..70673080)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72756548..73271851) , (72951303..73015309)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene tetra-peptide repeat homeobox-like protein Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene amyloid beta precursor protein binding protein 2 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1D Neighboring gene uncharacterized LOC134480844 Neighboring gene T-box transcription factor 2 Neighboring gene T-box transcription factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human BCAS3 expression in embryonic stem cells and vascular precursors suggests a role in human embryogenesis and tumor angiogenesis. Siva K, et al. PLoS One, 2007 Nov 21. PMID 18030336, Free PMC Article
  2. Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer. Gururaj AE, et al. Cell Cycle, 2006 Jul. PMID 16855396
  3. Rudhira/BCAS3 is a cytoskeletal protein that controls Cdc42 activation and directional cell migration during angiogenesis. Jain M, et al. Exp Cell Res, 2012 Apr 1. PMID 22300583
  4. Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1). Gururaj AE, et al. Mol Endocrinol, 2007 Aug. PMID 17505058
  5. Rudhira is a cytoplasmic WD40 protein expressed in mouse embryonic stem cells and during embryonic erythropoiesis. Siva K, et al. Gene Expr Patterns, 2006 Jan. PMID 16099728

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetyltransferase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to estrogen stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in phagophore assembly site ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BCAS3 microtubule associated cell migration factor
Names
breast carcinoma amplified sequence 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173430.1 → NP_001166901.1  BCAS3 microtubule associated cell migration factor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6A420, A6HHP1
    Conserved Domains (1) summary
    pfam12490
    Location:581 → 756
    BCAS3; Breast carcinoma amplified sequence 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    70711084..71170492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086499.2 → XP_038942427.1  BCAS3 microtubule associated cell migration factor isoform X7

    UniProtKB/TrEMBL
    A0A8I6ASA0, A0A8I6AT23
    Related
    ENSRNOP00000097649.1
    Conserved Domains (1) summary
    pfam12490
    Location:581 → 756
    BCAS3; Breast carcinoma amplified sequence 3

  2. XM_063269534.1 → XP_063125604.1  BCAS3 microtubule associated cell migration factor isoform X1

    UniProtKB/TrEMBL
    A0A8I6GK77

  3. XM_039086495.2 → XP_038942423.1  BCAS3 microtubule associated cell migration factor isoform X3

    UniProtKB/TrEMBL
    A0A8I6ASA0, A0A8I6G9E5
    Related
    ENSRNOP00000082383.1
    Conserved Domains (1) summary
    pfam12490
    Location:581 → 756
    BCAS3; Breast carcinoma amplified sequence 3

  4. XM_039086494.2 → XP_038942422.1  BCAS3 microtubule associated cell migration factor isoform X2

    UniProtKB/TrEMBL
    A6HHP1
    Conserved Domains (1) summary
    pfam12490
    Location:581 → 756
    BCAS3; Breast carcinoma amplified sequence 3

  5. XM_039086497.2 → XP_038942425.1  BCAS3 microtubule associated cell migration factor isoform X5

    UniProtKB/TrEMBL
    A0A8I6ASA0
    Related
    ENSRNOP00000092518.1
    Conserved Domains (1) summary
    pfam12490
    Location:521 → 741
    BCAS3; Breast carcinoma amplified sequence 3

  6. XM_063269537.1 → XP_063125607.1  BCAS3 microtubule associated cell migration factor isoform X9

  7. XM_039086498.2 → XP_038942426.1  BCAS3 microtubule associated cell migration factor isoform X6

    UniProtKB/TrEMBL
    A0A8I6A420, A6HHP1
    Related
    ENSRNOP00000087925.1
    Conserved Domains (1) summary
    pfam12490
    Location:581 → 756
    BCAS3; Breast carcinoma amplified sequence 3

  8. XM_039086496.2 → XP_038942424.1  BCAS3 microtubule associated cell migration factor isoform X4

    UniProtKB/TrEMBL
    A0A8I6APN6, A0A8I6ASA0
    Related
    ENSRNOP00000096642.1
    Conserved Domains (1) summary
    pfam12490
    Location:521 → 741
    BCAS3; Breast carcinoma amplified sequence 3

  9. XM_039086500.2 → XP_038942428.1  BCAS3 microtubule associated cell migration factor isoform X8

    UniProtKB/TrEMBL
    A0A8I6ASA0
    Conserved Domains (1) summary
    pfam12490
    Location:521 → 741
    BCAS3; Breast carcinoma amplified sequence 3

  10. XM_063269533.1 → XP_063125603.1  BCAS3 microtubule associated cell migration factor isoform X1

    UniProtKB/TrEMBL
    A0A8I6GK77

  11. XM_063269535.1 → XP_063125605.1  BCAS3 microtubule associated cell migration factor isoform X6

    UniProtKB/TrEMBL
    A0A8I6A420

  12. XM_063269536.1 → XP_063125606.1  BCAS3 microtubule associated cell migration factor isoform X8

RNA

  1. XR_010055214.1 RNA Sequence

  2. XR_010055215.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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