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Hira histone cell cycle regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 363849, updated on 13-Apr-2024

Summary

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Symbol
Hiraprovided by RGD
Full Name
histone cell cycle regulatorprovided by RGD
Primary source
RGD:1584950
See related
Ensembl:ENSRNOG00000045770 AllianceGenome:RGD:1584950
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and histone binding activity. Predicted to contribute to nucleosome binding activity. Predicted to be involved in DNA replication-independent chromatin assembly. Predicted to act upstream of or within gastrulation; muscle cell differentiation; and osteoblast differentiation. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of HIR complex. Orthologous to human HIRA (histone cell cycle regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 58.7), Thymus (RPKM 53.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q23
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (95528831..95637565, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82024469..82133212, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86168196..86276430, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda constant 1 Neighboring gene uncharacterized LOC134480931 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene mitochondrial ribosomal protein L40 Neighboring gene similar to human chromosome 22 open reading frame 39

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote. van der Heijden GW, et al. Mech Dev, 2005 Sep. PMID 15922569
  2. The role of histone chaperones in osteoblastic differentiation of C2C12 myoblasts. Song TY, et al. Biochem Biophys Res Commun, 2012 Jul 13. PMID 22705305
  3. Histone chaperones in nucleosome assembly and human disease. Burgess RJ, et al. Nat Struct Mol Biol, 2013 Jan. PMID 23288364, Free PMC Article
  4. Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality. Roberts C, et al. Mol Cell Biol, 2002 Apr. PMID 11884616, Free PMC Article
  5. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Tagami H, et al. Cell, 2004 Jan 9. PMID 14718166

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within gastrulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of HIR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein HIRA
Names
HIR histone cell cycle regulation defective homolog A
histone cell cycle regulation defective homolog A
protein HIRA-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135760.1 → NP_001129232.1  protein HIRA

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    M0R4R2
    Related
    ENSRNOP00000064357.1, ENSRNOT00000075164.2
    Conserved Domains (5) summary
    COG2319
    Location:7 → 372
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:7 → 352
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam07569
    Location:761 → 952
    Hira; TUP1-like enhancer of split
    pfam09453
    Location:448 → 469
    HIRA_B; HIRA B motif
    sd00039
    Location:16 → 61
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    95528831..95637565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270679.1 → XP_063126749.1  protein HIRA isoform X2

  2. XM_063270678.1 → XP_063126748.1  protein HIRA isoform X1

    UniProtKB/TrEMBL
    M0R756

  3. XM_063270681.1 → XP_063126751.1  protein HIRA isoform X3

  4. XM_063270680.1 → XP_063126750.1  protein HIRA isoform X3

  5. XM_063270682.1 → XP_063126752.1  protein HIRA isoform X3

  6. XM_063270683.1 → XP_063126753.1  protein HIRA isoform X4

RNA

  1. XR_010055965.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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