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Rad9b RAD9 checkpoint clamp component B [ Rattus norvegicus (Norway rat) ]

Gene ID: 363924, updated on 2-May-2024

Summary

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Official Symbol
Rad9bprovided by RGD
Official Full Name
RAD9 checkpoint clamp component Bprovided by RGD
Primary source
RGD:1308223
See related
Ensembl:ENSRNOG00000021480 AllianceGenome:RGD:1308223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in DNA integrity checkpoint signaling; DNA repair; and cellular response to ionizing radiation. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Orthologous to human RAD9B (RAD9 checkpoint clamp component B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 80.5), Muscle (RPKM 52.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rad9b in Genome Data Viewer
Location:
12q16
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (39878221..39909254)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (34217868..34248380)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (39699076..39731218)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene GPN-loop GTPase 3 Neighboring gene family with sequence similarity 216, member A Neighboring gene uncharacterized LOC134481297 Neighboring gene VPS29 retromer complex component Neighboring gene uncharacterized LOC108352448 Neighboring gene protein phosphatase targeting COQ7 Neighboring gene tectonic family member 1 Neighboring gene hydrogen voltage-gated channel 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue. Hopkins KM, et al. Cancer Res, 2003 Sep 1. PMID 14500360
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of RAD9B in the mesostriatal system of rats and humans: Overexpression in a 6-OHDA rat model of Parkinson's disease.
    Title: Expression of RAD9B in the mesostriatal system of rats and humans: Overexpression in a 6-OHDA rat model of Parkinson's disease.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC124758

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of checkpoint clamp complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell cycle checkpoint control protein RAD9B
Names
DNA repair exonuclease rad9 homolog B
cell cycle checkpoint control protein RAD9B homolog
NP_001025213.2
XP_008767463.1
XP_008767466.1
XP_017453901.1
XP_017453902.1
XP_038945561.1
XP_038945562.1
XP_038945563.1
XP_038945565.1
XP_063127631.1
XP_063127632.1
XP_063127633.1
XP_063127634.1
XP_063127635.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030042.2 → NP_001025213.2  cell cycle checkpoint control protein RAD9B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q499V3
    UniProtKB/TrEMBL
    A0A8L2QM66, A6J1A5
    Related
    ENSRNOP00000042520.4, ENSRNOT00000048454.4
    Conserved Domains (1) summary
    pfam04139
    Location:21 → 278
    Rad9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    39878221..39909254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271562.1 → XP_063127632.1  cell cycle checkpoint control protein RAD9B isoform X3

  2. XM_063271561.1 → XP_063127631.1  cell cycle checkpoint control protein RAD9B isoform X1

    UniProtKB/TrEMBL
    A6J1A6

  3. XM_039089633.2 → XP_038945561.1  cell cycle checkpoint control protein RAD9B isoform X1

    UniProtKB/TrEMBL
    A6J1A6
    Conserved Domains (1) summary
    pfam04139
    Location:1 → 165
    Rad9

  4. XM_017598412.3 → XP_017453901.1  cell cycle checkpoint control protein RAD9B isoform X1

    UniProtKB/TrEMBL
    A6J1A6
    Conserved Domains (1) summary
    pfam04139
    Location:1 → 165
    Rad9

  5. XM_063271563.1 → XP_063127633.1  cell cycle checkpoint control protein RAD9B isoform X1

    UniProtKB/TrEMBL
    A6J1A6

  6. XM_063271565.1 → XP_063127635.1  cell cycle checkpoint control protein RAD9B isoform X7

  7. XM_008769241.3 → XP_008767463.1  cell cycle checkpoint control protein RAD9B isoform X2

    UniProtKB/Swiss-Prot
    Q499V3
    Conserved Domains (2) summary
    cd00577
    Location:17 → 257
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam04139
    Location:21 → 258
    Rad9; Rad9

  8. XM_039089637.2 → XP_038945565.1  cell cycle checkpoint control protein RAD9B isoform X5

    Conserved Domains (1) summary
    pfam04139
    Location:21 → 257
    Rad9

  9. XM_039089634.2 → XP_038945562.1  cell cycle checkpoint control protein RAD9B isoform X4

    Conserved Domains (1) summary
    pfam04139
    Location:21 → 203
    Rad9

  10. XM_063271564.1 → XP_063127634.1  cell cycle checkpoint control protein RAD9B isoform X6

  11. XM_017598413.3 → XP_017453902.1  cell cycle checkpoint control protein RAD9B isoform X1

    UniProtKB/TrEMBL
    A6J1A6
    Conserved Domains (1) summary
    pfam04139
    Location:1 → 165
    Rad9

  12. XM_039089635.2 → XP_038945563.1  cell cycle checkpoint control protein RAD9B isoform X1

    UniProtKB/TrEMBL
    A6J1A6
    Conserved Domains (1) summary
    pfam04139
    Location:1 → 165
    Rad9

  13. XM_008769244.4 → XP_008767466.1  cell cycle checkpoint control protein RAD9B isoform X1

    See identical proteins and their annotated locations for XP_008767466.1

    UniProtKB/TrEMBL
    A6J1A6
    Conserved Domains (1) summary
    pfam04139
    Location:1 → 165
    Rad9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q499V3.1 GenPept UniProtKB/Swiss-Prot:Q499V3

Gene LinkOut

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