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Slamf7 SLAM family member 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364049, updated on 13-Apr-2024

Summary

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Official Symbol
Slamf7provided by RGD
Official Full Name
SLAM family member 7provided by RGD
Primary source
RGD:1560190
See related
Ensembl:ENSRNOG00000023209 AllianceGenome:RGD:1560190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560190
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in T cell activation. Predicted to act upstream of or within regulation of natural killer cell activation. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human SLAMF7 (SLAM family member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 228.3), Thymus (RPKM 177.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86668060..86688222, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (84135656..84154528, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (90056726..90075159, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 9 Neighboring gene uncharacterized LOC102549964 Neighboring gene uncharacterized LOC103692286 Neighboring gene Cd48 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cutting edge: NTB-A activates NK cells via homophilic interaction. Flaig RM, et al. J Immunol, 2004 Jun 1. PMID 15153464
  2. Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Cruz-Munoz ME, et al. Nat Immunol, 2009 Mar. PMID 19151721
  3. Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells. Dong Z, et al. Nat Immunol, 2009 Sep. PMID 19648922
  4. A secreted protein microarray platform for extracellular protein interaction discovery. Ramani SR, et al. Anal Biochem, 2012 Jan 15. PMID 21982860
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of natural killer cell activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SLAM family member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412827.1 → NP_001399756.1  SLAM family member 7 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A0G2K5F6
    Related
    ENSRNOP00000073407.1, ENSRNOT00000088884.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    86668060..86688222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090954.2 → XP_038946882.1  SLAM family member 7 isoform X1

    UniProtKB/TrEMBL
    A6JG06, D4ABU3
    Related
    ENSRNOP00000038176.5
    Conserved Domains (2) summary
    cd00096
    Location:27 → 32
    Ig; Ig strand A [structural motif]
    cl11960
    Location:27 → 123
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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