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Smim14 small integral membrane protein 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364154, updated on 3-Apr-2024

Summary

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Official Symbol
Smim14provided by RGD
Official Full Name
small integral membrane protein 14provided by RGD
Primary source
RGD:1311122
See related
Ensembl:ENSRNOG00000066377 AllianceGenome:RGD:1311122
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311122
Summary
Predicted to act upstream of or within blastocyst hatching. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human SMIM14 (small integral membrane protein 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 277.4), Adrenal (RPKM 272.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Smim14 in Genome Data Viewer
Location:
14p11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (43136754..43180622)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (42783361..42829762)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (44413636..44460044)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene PDS5 cohesin associated factor A Neighboring gene ribosomal protein L14 like 2 Neighboring gene ubiquitin-conjugating enzyme E2K Neighboring gene ribosomal protein lateral stalk subunit P2 like 3 Neighboring gene UDP-glucose 6-dehydrogenase Neighboring gene lipoic acid synthetase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the cellular localization of C4orf34 as a novel endoplasmic reticulum resident protein. Jun MH, et al. BMB Rep, 2014 Oct. PMID 24499674, Free PMC Article
  2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC116420

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small integral membrane protein 14
Names
uncharacterized protein C4orf34 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037792.1 → NP_001032881.1  small integral membrane protein 14

    See identical proteins and their annotated locations for NP_001032881.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100271
    UniProtKB/Swiss-Prot
    Q498C7
    UniProtKB/TrEMBL
    A6JDD7
    Related
    ENSRNOP00000085533.1, ENSRNOT00000099960.1
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    43136754..43180622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273436.1 → XP_063129506.1  small integral membrane protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q498C7
    UniProtKB/TrEMBL
    A6JDD7

  2. XM_063273434.1 → XP_063129504.1  small integral membrane protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q498C7
    UniProtKB/TrEMBL
    A6JDD7

  3. XM_063273438.1 → XP_063129508.1  small integral membrane protein 14 isoform X2

  4. XM_039092247.2 → XP_038948175.1  small integral membrane protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q498C7
    UniProtKB/TrEMBL
    A6JDD7
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

  5. XM_039092250.2 → XP_038948178.1  small integral membrane protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q498C7
    UniProtKB/TrEMBL
    A6JDD7
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

  6. XM_039092248.2 → XP_038948176.1  small integral membrane protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q498C7
    UniProtKB/TrEMBL
    A6JDD7
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

  7. XM_039092249.2 → XP_038948177.1  small integral membrane protein 14 isoform X1

    UniProtKB/Swiss-Prot
    Q498C7
    UniProtKB/TrEMBL
    A6JDD7
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

  8. XM_006250961.5 → XP_006251023.1  small integral membrane protein 14 isoform X1

    See identical proteins and their annotated locations for XP_006251023.1

    UniProtKB/Swiss-Prot
    Q498C7
    UniProtKB/TrEMBL
    A6JDD7
    Conserved Domains (1) summary
    pfam11027
    Location:3 → 97
    DUF2615; Protein of unknown function (DUF2615)

  9. XM_063273437.1 → XP_063129507.1  small integral membrane protein 14 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q498C7.1 GenPept UniProtKB/Swiss-Prot:Q498C7

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