Kcnk5 potassium two pore domain channel subfamily K member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnk5provided by RGD
Official Full Name: potassium two pore domain channel subfamily K member 5provided by RGD
Primary source: RGD:1564985
See related: Ensembl:ENSRNOG00000047005 AllianceGenome:RGD:1564985
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TASK2
Summary: Predicted to enable potassium ion leak channel activity and voltage-gated potassium channel activity. Predicted to be involved in potassium ion export across plasma membrane and stabilization of membrane potential. Predicted to act upstream of or within potassium ion import across plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human KCNK5 (potassium two pore domain channel subfamily K member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 120.6), Liver (RPKM 56.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (4171625..4213896)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (4122442..4164718)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (4554603..4597000)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that expression of TASK-2 and TASK-3 (but not TASK-1) undergoes age-related changes in dorsal root ganglion (DRG) neurons; TASK-2 and TASK-3 are likely to contribute to resting membrane potential in DRG neurons in neonates and adults.
Title: Age-related changes in two-pore domain acid-sensitive K⁺ channel expression in rat dorsal root ganglion neurons.
In contrast to weak expression in the outer retina, TASK-2 is strongly expressed in the inner retina. TASK-2 immunoreactivity was diffusely distributed throughout the inner plexiform layer.(TASK-2)
Title: TASK-2 is expressed in proximal neurons in the rat retina.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of resting membrane potential	ISO Inferred from Sequence Orthology more info
involved_in stabilization of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium channel subfamily K member 5

Names: potassium channel, subfamily K, member 5; potassium channel, two pore domain subfamily K, member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.