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Tnfrsf10b TNF receptor superfamily member 10b [ Rattus norvegicus (Norway rat) ]

Gene ID: 364420, updated on 2-May-2024

Summary

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Official Symbol
Tnfrsf10bprovided by RGD
Official Full Name
TNF receptor superfamily member 10bprovided by RGD
Primary source
RGD:1308041
See related
Ensembl:ENSRNOG00000038483 AllianceGenome:RGD:1308041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and protease binding activity. Involved in extrinsic apoptotic signaling pathway via death domain receptors; male gonad development; and response to organic cyclic compound. Located in membrane. Biomarker of colon cancer and osteoarthritis. Human ortholog(s) of this gene implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Orthologous to human TNFRSF10A (TNF receptor superfamily member 10a). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 18.0), Liver (RPKM 14.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tnfrsf10b in Genome Data Viewer
Location:
15p11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (51249883..51278091)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (44840386..44868318)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (51433853..51464215)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene R3H domain and coiled-coil containing 1 Neighboring gene charged multivesicular body protein 7 Neighboring gene Rho-related BTB domain containing 2 Neighboring gene uncharacterized LOC103693695 Neighboring gene uncharacterized LOC102550955

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Anti-DR5 mAb ameliorate adjuvant arthritis rats through inducing synovial cells apoptosis. Li W, et al. Exp Biol Med (Maywood), 2009 Dec. PMID 19934367
  2. [Expression of tumor necrosis factor related apoptosis inducing ligand and its receptor in thymus during early post-burn stage in rat with severe burns]. Leng XF, et al. Zhonghua Shao Shang Za Zhi, 2007 Jun. PMID 18019056
  3. Combined natural killer T-cell based immunotherapy eradicates established tumors in mice. Teng MW, et al. Cancer Res, 2007 Aug 1. PMID 17671220
  4. Chemopreventive effects of lupulone, a hop {beta}-acid, on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Lamy V, et al. Carcinogenesis, 2007 Jul. PMID 17434926
  5. Efficacy of anti-death receptor 5 (DR5) antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue slice model. Estes JM, et al. Gynecol Oncol, 2007 May. PMID 17303227

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DR5-mediated EGFR-transactivation promotes cardiomyocyte hypertrophic gene transcription.
    Title: Death receptor 5 contributes to cardiomyocyte hypertrophy through epidermal growth factor receptor transactivation.
  2. The present study demonstrates that TRAIL and DR5 were highly expressed in the cerebral cortexes of newborn rats 24 h after hypoxia-ischemia
    Title: Hypoxia-ischemia upregulates TRAIL and TRAIL receptors in the immature rat brain.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables TRAIL binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in TRAIL-activated apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in extrinsic apoptotic signaling pathway via death domain receptors IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male gonad development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 10B
Names
tumor necrosis factor receptor superfamily, member 10b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395720.2 → NP_001382649.1  tumor necrosis factor receptor superfamily member 10B precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A0G2JZE1, B8YBG7
    Related
    ENSRNOP00000071012.2, ENSRNOT00000077758.2
    Conserved Domains (2) summary
    cd08315
    Location:243 → 329
    Death_TRAILR_DR4_DR5; Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors
    cd10580
    Location:34 → 133
    TNFRSF10; Tumor necrosis factor receptor superfamily member 10 (TNFRSF10), includes TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    51249883..51278091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274494.1 → XP_063130564.1  tumor necrosis factor receptor superfamily member 10B isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108873.1: Suppressed sequence

    Description
    NM_001108873.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous