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B4galt7 beta-1,4-galactosyltransferase 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364675, updated on 5-Mar-2024

Summary

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Official Symbol
B4galt7provided by RGD
Official Full Name
beta-1,4-galactosyltransferase 7provided by RGD
Primary source
RGD:1309214
See related
Ensembl:ENSRNOG00000021886 AllianceGenome:RGD:1309214
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; manganese ion binding activity; and xylosylprotein 4-beta-galactosyltransferase activity. Predicted to be involved in several processes, including glycoprotein biosynthetic process; glycosaminoglycan biosynthetic process; and negative regulation of fibroblast proliferation. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome spondylodysplastic type 1. Orthologous to human B4GALT7 (beta-1,4-galactosyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 45.6), Muscle (RPKM 44.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
17p14
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9023667..9032742, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9018514..9027591, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9549605..9558672, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 46 Neighboring gene transfer RNA serine (anticodon AGA) 29 Neighboring gene calcium modulating ligand Neighboring gene transmembrane p24 trafficking protein 9 Neighboring gene family with sequence similarity 193, member B Neighboring gene uncharacterized LOC108348505

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystal structures of β-1,4-galactosyltransferase 7 enzyme reveal conformational changes and substrate binding. Tsutsui Y, et al. J Biol Chem, 2013 Nov 1. PMID 24052259, Free PMC Article
  2. Molecular basis for the progeroid variant of Ehlers-Danlos syndrome. Identification and characterization of two mutations in galactosyltransferase I gene. Okajima T, et al. J Biol Chem, 1999 Oct 8. PMID 10506123
  3. Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene family. Almeida R, et al. J Biol Chem, 1999 Sep 10. PMID 10473568
  4. Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin fibroblasts of an Ehlers-Danlos syndrome patient carrying the novel Arg270Cys substitution in galactosyltransferase I (beta4GalT-7). Seidler DG, et al. J Mol Med (Berl), 2006 Jul. PMID 16583246
  5. Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans. Okajima T, et al. J Biol Chem, 1999 Aug 13. PMID 10438455

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC116242

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables xylosylprotein 4-beta-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables xylosylprotein 4-beta-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteoglycan metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in supramolecular fiber organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
beta-1,4-galactosyltransferase 7
Names
xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
NP_001026831.1
XP_008769723.1
XP_038951894.1
XP_063132733.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031661.1 → NP_001026831.1  beta-1,4-galactosyltransferase 7

    See identical proteins and their annotated locations for NP_001026831.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099103
    UniProtKB/TrEMBL
    F7ETN7, Q4FZU7
    Related
    ENSRNOP00000029002.4, ENSRNOT00000036223.5
    Conserved Domains (1) summary
    cd00899
    Location:92 → 315
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    9023667..9032742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771501.4 → XP_008769723.1  beta-1,4-galactosyltransferase 7 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4C0, F7ETN7
    Related
    ENSRNOP00000072981.1
    Conserved Domains (1) summary
    cd00899
    Location:146 → 369
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

  2. XM_039095966.2 → XP_038951894.1  beta-1,4-galactosyltransferase 7 isoform X3

    Conserved Domains (1) summary
    cd00899
    Location:1 → 201
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

  3. XM_063276663.1 → XP_063132733.1  beta-1,4-galactosyltransferase 7 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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