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Suv39h2 SUV39H2 histone lysine methyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 364785, updated on 11-Apr-2024

Summary

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Official Symbol
Suv39h2provided by RGD
Official Full Name
SUV39H2 histone lysine methyltransferaseprovided by RGD
Primary source
RGD:1306969
See related
Ensembl:ENSRNOG00000015585 AllianceGenome:RGD:1306969
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; cation binding activity; and histone methyltransferase activity (H3-K9 specific). Predicted to be involved in several processes, including chromatin organization; histone H3-K9 methylation; and negative regulation of circadian rhythm. Predicted to act upstream of or within several processes, including cellular response to hypoxia; histone H3-K9 methylation; and male meiotic nuclear division. Predicted to be located in heterochromatin. Predicted to be active in nucleus. Orthologous to human SUV39H2 (SUV39H2 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 55.2), Testes (RPKM 30.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
17q12.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (79665467..79684492)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (74756290..74775332)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (78762897..78782016)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482747 Neighboring gene cerebral dopamine neurotrophic factor Neighboring gene Myb/SANT DNA binding domain containing 7 Neighboring gene heat shock protein family A (Hsp70) member 14 Neighboring gene uncharacterized LOC120097881 Neighboring gene DNA cross-link repair 1C Neighboring gene metallothionein 1, pseudogene 3 Neighboring gene meiosis/spermiogenesis associated 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. Jack AP, et al. PLoS One, 2013. PMID 23451023, Free PMC Article
  2. Targeting protein lysine methylation and demethylation in cancers. He Y, et al. Acta Biochim Biophys Sin (Shanghai), 2012 Jan. PMID 22194015, Free PMC Article
  3. Structural biology of human H3K9 methyltransferases. Wu H, et al. PLoS One, 2010 Jan 11. PMID 20084102, Free PMC Article
  4. Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states. Wu R, et al. Mol Biol Cell, 2005 Jun. PMID 15788566, Free PMC Article
  5. Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. O'Carroll D, et al. Mol Cell Biol, 2000 Dec. PMID 11094092, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H3 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K9 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K9 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K9 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K9me2 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in epigenetic programming in the zygotic pronuclei ISO
Inferred from Sequence Orthology
more info
  
involved_in male meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histone-lysine N-methyltransferase SUV39H2
Names
suppressor of variegation 3-9 homolog 2
NP_001102353.1
XP_038951911.1
XP_063132746.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108883.1 → NP_001102353.1  histone-lysine N-methyltransferase SUV39H2

    See identical proteins and their annotated locations for NP_001102353.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473990
    UniProtKB/TrEMBL
    A6JM14, D3ZIH5
    Related
    ENSRNOP00000020924.3, ENSRNOT00000020924.5
    Conserved Domains (4) summary
    smart00317
    Location:321 → 450
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG2940
    Location:236 → 481
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    pfam00385
    Location:119 → 164
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
    pfam05033
    Location:225 → 313
    Pre-SET; Pre-SET motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    79665467..79684492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095983.2 → XP_038951911.1  histone-lysine N-methyltransferase SUV39H2 isoform X1

    Conserved Domains (2) summary
    cd18639
    Location:148 → 196
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cd10532
    Location:268 → 510
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins

  2. XM_063276676.1 → XP_063132746.1  histone-lysine N-methyltransferase SUV39H2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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